T
Thota Sambaiah
Researcher at Purdue University
Publications - 8
Citations - 145
Thota Sambaiah is an academic researcher from Purdue University. The author has contributed to research in topics: Lumazine synthase & Chloride. The author has an hindex of 5, co-authored 8 publications receiving 140 citations.
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Journal ArticleDOI
Design, Synthesis, and Evaluation of 9-d-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase
TL;DR: Interestingly, the enzyme kinetics of these new compounds in comparison with the parent purinetrione demonstrated unexpectedly that the phosphate and phosphonate substituents contributed negatively to the binding.
Journal ArticleDOI
Structural and Thermodynamic Insights Into the Binding Mode of Five Novel Inhibitors of Lumazine Synthase from Mycobacterium Tuberculosis.
Ekaterina Morgunova,Boris Illarionov,Thota Sambaiah,Ilka Haase,Adelbert Bacher,Mark Cushman,Markus Fischer,Rudolf Ladenstein +7 more
TL;DR: The ribitylpurinetrione compounds with C4–C5 alkylphosphate chains with high affinity and specificity to lumazine synthase are proposed as most promising leads for further development of therapeutic drugs against M. tuberculosis.
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Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes.
TL;DR: Replacement of the ribitylamino N-H moiety with epimeric C-F moieties led to inhibition of lumazine synthase and riboflavin synthase when combined with the replacement of the 5-amino group with a nitro substituent.
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Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis
Ekaterina Morgunova,Boris Illarionov,Sabine Saller,Aleksander Popov,Thota Sambaiah,Adelbert Bacher,Mark Cushman,Markus Fischer,Rudolf Ladenstein +8 more
TL;DR: Crystallographic studies of lumazine synthase, the penultimate enzyme of the riboflavin-biosynthetic pathway in B. anthracis, provide a structural framework for the design of antibiotic inhibitors together with calorimetric and kinetic investigations of inhibitor binding.
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Regioselective 1-O-Acyl Hydrolysis of Peracylated Glycopyranoses by Mercuric Chloride and Mercuric Oxide.
TL;DR: Cushman et al. as discussed by the authors proposed a 1-O-Acyl Hydrolysis of Peracylated Glycopyranoses (PHG) for the first time.