T
Tian Yow Tsong
Researcher at University of Minnesota
Publications - 177
Citations - 10130
Tian Yow Tsong is an academic researcher from University of Minnesota. The author has contributed to research in topics: Electric field & Protein folding. The author has an hindex of 52, co-authored 177 publications receiving 9853 citations. Previous affiliations of Tian Yow Tsong include University of the Sciences & Hong Kong University of Science and Technology.
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Journal ArticleDOI
Electroporation of cell membranes.
TL;DR: Electroporation has found applications in introduction of plasmids or foreign DNA into living cells for gene transfections, fusion of cells to prepare heterokaryons, hybridoma, hybrid embryos, and constructing animal model by fusing human cells with animal tissues.
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Formation and resealing of pores of controlled sizes in human erythrocyte membrane
Kazuhiko Kinosita,Tian Yow Tsong +1 more
TL;DR: It is shown that the size of these pores can be varied in a controlled manner, and that the leaky membrane can be resealed while the haemolysis is prevented, and foreign molecules have successfully been incorporated into the resealed, but otherwise intact, erythrocytes.
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Voltage-induced pore formation and hemolysis of human erythrocytes.
Kazuhiko Kinosita,Tian Yow Tsong +1 more
TL;DR: Isotonic suspensions of human erythrocytes were exposed to single electric pulses of intensity at a few kV/cm and duration in microseconds, and the cell membranes became permeable to Na+ and K+ and hemolysed through the colloid osmotic effect of hemoglobin.
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Electric field induced transient pores in phospholipid bilayer vesicles.
Justin Teissié,Tian Yow Tsong +1 more
TL;DR: Experiments show that these pores were fully reversible, and no global and permanent damages to the vesicle bilayer were detected, and the implication of this membrane potential triggered conducting state of lipid bilayers to biological functions of cells is discussed.
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Hemolysis of human erythrocytes by transient electric field
Kazuhiko Kinosita,Tian Yow Tsong +1 more
TL;DR: Kinetic measurements indicate that the hemolysis of the red cells follows a stepwise mechanism: leakage of ions leads to an osmotic imbalance which in turn causes a colloidal hemolyses of thered cells.