T
Tianquan Zhu
Researcher at University of Michigan
Publications - 3
Citations - 3285
Tianquan Zhu is an academic researcher from University of Michigan. The author has contributed to research in topics: Protein kinase B & PI3K/AKT/mTOR pathway. The author has an hindex of 2, co-authored 3 publications receiving 2981 citations.
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
TL;DR: It is shown that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 and activates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translational initiation) and these functions are mediated by inhibition of the mammalian target of rapamycin (mTOR).
Journal ArticleDOI
Negative regulation of the serine/threonine kinase B-Raf by Akt.
Kun-Liang Guan,Claudia Figueroa,Teresa R. Brtva,Tianquan Zhu,Jennifer K. Taylor,Theodore D. Barber,Anne B. Vojtek +6 more
TL;DR: It is demonstrated that B-Raf activity can be negatively regulated by Akt through phosphorylation in the amino-terminal regulatory domain of B- Raf, which is likely to play an important role in modulating the signaling specificity of the Ras/Raf pathway and in promoting biological outcome.