Anne B. Vojtek

TL;DR: Ras is a key regulator of cell growth in all eukaryotic cells and the frequency of Ras mutations is likely to be an underestimation of the contribution of aberrant signaling through the Ras pathway to human malignancies because chronic up-regulation of the Ras pathways can occur in the absence of mutations in Ras itself.

TL;DR: New RNA polymerase II expression vectors for RNAi are developed, designated SIBR vectors, based upon the non-coding RNA BIC, and it is found that expression of a short region of the third exon of mouse BIC is sufficient to produce miR-155 in mammalian cells.

TL;DR: It is demonstrated that B-Raf activity can be negatively regulated by Akt through phosphorylation in the amino-terminal regulatory domain of B- Raf, which is likely to play an important role in modulating the signaling specificity of the Ras/Raf pathway and in promoting biological outcome.

TL;DR: A novel p110 isoform of phosphatidylinositol 3-kinase from human leukocytes that is expressed at high levels in lymphocytes and lymphoid tissues and may therefore play a role in phosphate-based signaling in the immune system.

TL;DR: The identification of a core set of regeneration-associated signaling pathways required for MG reprogramming not only furthers the understanding of retina regeneration in fish but also suggests targets for enhancing regeneration in mammals.