T
Tiansen Li
Researcher at National Institutes of Health
Publications - 113
Citations - 10658
Tiansen Li is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 54, co-authored 112 publications receiving 9789 citations. Previous affiliations of Tiansen Li include Harvard University & Massachusetts Eye and Ear Infirmary.
Papers
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Journal ArticleDOI
Sexual development and fertility of Loxl1-/- male mice.
Hadley M. Wood,Una J. Lee,Drina Vurbic,Edmund Sabanegh,Jonathan H. Ross,Tiansen Li,Margot S. Damaser,Margot S. Damaser,Margot S. Damaser +8 more
TL;DR: A subtle and likely multifactorial role of the LOXL1 protein in male sexual development and fertility is suggested, suggesting a component of male-factor infertility.
Journal ArticleDOI
Increased Light Exposure Alleviates One Form of Photoreceptor Degeneration Marked by Elevated Calcium in the Dark
Xiaoqing Liu,Basil S. Pawlyk,Michael Adamian,Elena V. Olshevskaya,Alexander M. Dizhoor,Clint L. Makino,Tiansen Li +6 more
TL;DR: In contrast to most forms of retinal degeneration, which are exacerbated by increased exposure to ambient light, a subset with mutations that cause overly active guanylyl cyclase and high intracellular calcium benefitted from prolonged light exposure.
Journal Article
RPGR gene editing with CRISPR-Cas 9 system in Retinal degeneration 9 (Rd9) mice to correct a disease mutation and phenotype
Amal Alsufyani,Amal Alsufyani,Wenhan Yu,Jessica D. Gumerson,Lijin Dong,Zhijian Wu,Tiansen Li +6 more
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Divergent Effects of HSP70 Overexpression in Photoreceptors During Inherited Retinal Degeneration.
Ke Jiang,Elizabeth Fairless,Atsuhiro Kanda,Norimoto Gotoh,Tiziana Cogliati,Tiansen Li,Anand Swaroop +6 more
TL;DR: HSP70 overexpression has divergent effects in photoreceptors determined, at least in part, by the nature of the mutant protein each model carries, suggesting an initial adaptive response to cellular stress.
Journal ArticleDOI
Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration.
Passley Hargrove-Grimes,Passley Hargrove-Grimes,Anupam Kumar Mondal,Jessica D. Gumerson,Jacob Nellissery,Angel Aponte,Linn Gieser,Haohua Qian,Robert N. Fariss,Juan S. Bonifacino,Tiansen Li,Anand Swaroop +11 more
TL;DR: This article showed that RabGEF1 and associated components are potential candidates for syndromic traits that include a retinopathy phenotype, suggesting an early trajectory of photoreceptor cell death.