T
Tiffany G. Sheu
Researcher at National Center for Immunization and Respiratory Diseases
Publications - 20
Citations - 1575
Tiffany G. Sheu is an academic researcher from National Center for Immunization and Respiratory Diseases. The author has contributed to research in topics: Neuraminidase & Oseltamivir. The author has an hindex of 16, co-authored 19 publications receiving 1529 citations. Previous affiliations of Tiffany G. Sheu include Battelle Memorial Institute.
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Journal ArticleDOI
Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008
Tiffany G. Sheu,Varough M. Deyde,Margaret Okomo-Adhiambo,Rebecca Garten,Xiyan Xu,Rick A. Bright,Eboneé N. Butler,Teresa R. Wallis,Alexander Klimov,Larisa V. Gubareva +9 more
TL;DR: The recent increase in oseltamivir resistance among A(H1N1) viruses isolated from untreated patients raises public health concerns and necessitates close monitoring of resistance to NA inhibitors.
Journal Article
Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009.
Larisa V. Gubareva,M. Okomo-Adhiambo,Varough M. Deyde,Alicia M. Fry,Tiffany G. Sheu,Rebecca Garten,Catherine H. Smith,John Barnes,A. Myrick,M. Hillman,Michael W. Shaw,Carolyn B. Bridges,Alexander Klimov,Nancy J. Cox +13 more
TL;DR: Detailed information is provided on the drug susceptibility of the newly detected S-OIVs, which will aid in making recommendations for treatment and prophylaxis for swine influenza A (H1N1) infection and contribute to antiviral-resistance monitoring and diagnostic test development.
Journal ArticleDOI
Detection of Molecular Markers of Drug Resistance in 2009 Pandemic Influenza A (H1N1) Viruses by Pyrosequencing
Varough M. Deyde,Tiffany G. Sheu,A. Angelica Trujillo,Margaret Okomo-Adhiambo,Rebecca Garten,Alexander Klimov,Larisa V. Gubareva +6 more
TL;DR: The detection of the first cases of the oseltamivir resistance-conferring mutation H275Y and the I223V change in viruses from the United States using the approach described in this study.
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Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro
Larisa V. Gubareva,A. Angelica Trujillo,Margaret Okomo-Adhiambo,Vasiliy P. Mishin,Varough M. Deyde,Katrina Sleeman,Ha T. Nguyen,Tiffany G. Sheu,Rebecca Garten,Michael W. Shaw,Alicia M. Fry,Alexander Klimov +11 more
TL;DR: The majority of 2009 pandemic influenza A (H1N1) surveillance viruses collected globally were resistant to adamantanes and sensitive to NAIs, except for H275Y variants, which exhibited approximately 100-fold reduction in peramivir susceptibility.
Journal ArticleDOI
Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses.
Varough M. Deyde,Margaret Okomo-Adhiambo,Tiffany G. Sheu,Teresa R. Wallis,Alicia M. Fry,Nila J. Dharan,Alexander Klimov,Larisa V. Gubareva +7 more
TL;DR: A pyrosequencing assay for detection of the most commonly reported mutations associated with resistance to NAIs, a newer class of anti-influenza drugs, and designed primers to detect substitutions at D151 in NAs of N1 and N2 subtypes.