H
Ha T. Nguyen
Researcher at National Center for Immunization and Respiratory Diseases
Publications - 34
Citations - 1444
Ha T. Nguyen is an academic researcher from National Center for Immunization and Respiratory Diseases. The author has contributed to research in topics: Neuraminidase & Oseltamivir. The author has an hindex of 21, co-authored 31 publications receiving 1195 citations. Previous affiliations of Ha T. Nguyen include Centers for Disease Control and Prevention & Battelle Memorial Institute.
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Journal ArticleDOI
Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods.
TL;DR: Close monitoring of antiviral resistance among all influenza viruses, both locally and globally, are essential to inform public health strategies for the control of influenza infections.
Journal ArticleDOI
Recovery of a Multidrug-Resistant Strain of Pandemic Influenza A 2009 (H1N1) Virus Carrying a Dual H275Y/I223R Mutation from a Child after Prolonged Treatment with Oseltamivir
TL;DR: A/Pennsylvania/30/2009 H275Y, I223R 4.72 0.43 (21) 8.75 (22) 3093.49 44.99 (12,374) 9324.21 119.08 (9053) 978.04 (13,092) Control A/West Virginia/11/2009 Wild type 0.22 0.13 0.03 (1) 0.24 0.25 0.35 0.39 0.
Journal ArticleDOI
Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018.
Emi Takashita,Rod S. Daniels,Seiichiro Fujisaki,Vicki Gregory,Larisa V. Gubareva,Weiijuan Huang,Aeron C. Hurt,Angie Lackenby,Ha T. Nguyen,Dmitriy Pereyaslov,Merryn Roe,Magdi Samaan,Kanta Subbarao,Herman Tse,Dayan Wang,Hui-Ling Yen,Wenqing Zhang,Adam Meijer +17 more
TL;DR: Overall, in the 2017-18 period the frequency of circulating influenza viruses with reduced susceptibility to NAIs or baloxavir was low, but continued monitoring is important.
Journal ArticleDOI
Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro
Larisa V. Gubareva,A. Angelica Trujillo,Margaret Okomo-Adhiambo,Vasiliy P. Mishin,Varough M. Deyde,Katrina Sleeman,Ha T. Nguyen,Tiffany G. Sheu,Rebecca Garten,Michael W. Shaw,Alicia M. Fry,Alexander Klimov +11 more
TL;DR: The majority of 2009 pandemic influenza A (H1N1) surveillance viruses collected globally were resistant to adamantanes and sensitive to NAIs, except for H275Y variants, which exhibited approximately 100-fold reduction in peramivir susceptibility.
Journal ArticleDOI
Host cell selection of influenza neuraminidase variants: Implications for drug resistance monitoring in A(H1N1) viruses
Margaret Okomo-Adhiambo,Ha T. Nguyen,Katrina Sleeman,Tiffany G. Sheu,Varough M. Deyde,Rebecca Garten,Xiyan Xu,Michael W. Shaw,Alexander Klimov,Larisa V. Gubareva +9 more
TL;DR: These findings provide evidence that propagation of influenza virus outside its natural host may lead to selection of virus variants with mutations in the NA that affect sensitivity to NAIs and thus poses implications for drug resistance monitoring and diagnostics.