Journal ArticleDOI
Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses.
Varough M. Deyde,Margaret Okomo-Adhiambo,Tiffany G. Sheu,Teresa R. Wallis,Alicia M. Fry,Nila J. Dharan,Alexander Klimov,Larisa V. Gubareva +7 more
TLDR
A pyrosequencing assay for detection of the most commonly reported mutations associated with resistance to NAIs, a newer class of anti-influenza drugs, and designed primers to detect substitutions at D151 in NAs of N1 and N2 subtypes.About:Â
This article is published in Antiviral Research.The article was published on 2009-01-01. It has received 89 citations till now. The article focuses on the topics: Influenza A virus & Neuraminidase.read more
Citations
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Infections With Oseltamivir-Resistant Influenza A(H1N1) Virus in the United States
Nila J. Dharan,Larisa V. Gubareva,John J. Meyer,Margaret Okomo-Adhiambo,Reginald C. McClinton,Steven A. Marshall,Kirsten St. George,Scott Epperson,Lynnette Brammer,Alexander Klimov,Joseph S. Bresee,Alicia M. Fry +11 more
TL;DR: Oseltamivir-resistant A(H1N1) viruses circulated widely in the United States during the 2007-2008 influenza season, appeared to be unrelated to oseltAMivir use, and appeared to cause illness similar to oselstamIVir-susceptible A( H1N 1) viruses.
Journal ArticleDOI
Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa.
Aeron C. Hurt,Joanne Rachel Ernest,Yi-Mo Deng,Pina Iannello,Terry G. Besselaar,Chris Birch,Philippe Buchy,Malinee Chittaganpitch,Shu-Chun Chiu,Dominic E. Dwyer,Aurélie Guigon,Bruce Harrower,Ip Peng Kei,Tuckweng Kok,Cui Lin,Ken McPhie,Apandi Mohd,Remigio M. Olveda,Tony Panayotou,William D. Rawlinson,Lesley Scott,David B. Smith,Holly D'Souza,Naomi Komadina,Robert Shaw,Anne Kelso,Ian G. Barr +26 more
TL;DR: Examination of 264 A(H1N1) viruses collected in 2008 from South Africa, Oceania and SE Asia for their susceptibility to NAIs oseltamivir, zanamvir and peramivIR in a fluorescence-based neuraminidase inhibition assay found H274Y mutant viruses demonstrated on average a 1466-fold reduction in oselTamivirs susceptibility and 527-fold reduced in peramavir sensitivity compared to wild-
Journal ArticleDOI
Antiviral resistance during the 2009 influenza A H1N1 pandemic: public health, laboratory, and clinical perspectives.
Aeron C. Hurt,Tawee Chotpitayasunondh,Nancy J. Cox,Rod S. Daniels,Alicia M. Fry,Larisa V. Gubareva,Frederick G. Hayden,Frederick G. Hayden,David S.C. Hui,Olav Hungnes,Angie Lackenby,Wilina Lim,Adam Meijer,Charles R. Penn,Masato Tashiro,Timothy M. Uyeki,Maria Zambon +16 more
TL;DR: Recommendations for antiviral susceptibility testing, reporting results, and management of patients infected with 2009 pandemic influenza A H1N1 are proposed and optimisation of antiviral treatment, rapid sample testing, and timely reporting of susceptibility results are proposed.
Journal ArticleDOI
Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication.
TL;DR: In this study, the anti-influenza A/WS/33 virus of quercetin 3-rhamnoside from Houttuynia cordata was evaluated using a cytopathic effect (CPE) reduction method, and the assay results demonstrated that Q3R possessed strong anti- influenza virus reducing the formation of a visible CPE.
Journal ArticleDOI
In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses.
Katrina Sleeman,Vasiliy P. Mishin,Varough M. Deyde,Yousuke Furuta,Alexander Klimov,Larisa V. Gubareva +5 more
TL;DR: Favipiravir inhibits in vitro replication of a wide range of influenza viruses, including those resistant to currently available drugs, including viruses which are resistant to the currently licensed anti-influenza drugs.
References
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Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection
de Jong,Tran Tt,Truong Hk,Vo Mh,Gavin J. D. Smith,Nguyen Vc,Bach Vc,Phan Tq,Do Qh,Yi Guan,Joseph Malik Sriyal Peiris,Tran Th,Jeremy Farrar +12 more
TL;DR: It is suggested that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
Journal ArticleDOI
Resistant influenza A viruses in children treated with oseltamivir: descriptive study
Maki Kiso,Keiko Mitamura,Yuko Sakai-Tagawa,Kyoko Shiraishi,Chiharu Kawakami,Kazuhiro Kimura,Frederick G. Hayden,Norio Sugaya,Yoshihiro Kawaoka,Yoshihiro Kawaoka +9 more
TL;DR: Sensitivity testing to oseltamivir carboxylate revealed that the neuraminidases of viruses that have an Arg292Lys, Glu119Val, or Asn294Ser mutation were about 10(4)-10(5)-fold, 500-fold, or 300-fold more resistant than their pretreatment neuraminIDases, respectively.
Journal ArticleDOI
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
Rupert J. Russell,Lesley F. Haire,D.J. Stevens,Patrick J. Collins,Yi Pu Lin,G. Michael Blackburn,Alan Hay,Steven J. Gamblin,John J. Skehel +8 more
TL;DR: It may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs, according to X-ray crystallography, which shows that these two groups of neuraminidases are structurally distinct.
Journal ArticleDOI
Avian flu: isolation of drug-resistant H5N1 virus.
Q. Mai Le,Maki Kiso,Kazuhiko Someya,Yuko T. Sakai,T. Hien Nguyen,Khan H. L. Nguyen,N. Dinh Pham,Ha H. Ngyen,Shinya Yamada,Yukiko Muramoto,Taisuke Horimoto,Ayato Takada,Hideo Goto,Takashi Suzuki,Yasuo Suzuki,Yoshihiro Kawaoka +15 more
TL;DR: The isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza is reported.
Journal ArticleDOI
Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern
Rick A. Bright,Marie-Jo Medina,Xiyan Xu,Gilda I. Perez-Oronoz,Teresa R. Wallis,Xiaohong M. Davis,Laura Povinelli,Nancy J. Cox,Alexander Klimov +8 more
TL;DR: The authors' data raise concerns about the appropriate use of adamantanes and draw attention to the importance of tracking the emergence and spread of drug-resistant influenza A viruses.