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Tim C. Diss

Researcher at University College London

Publications -  52
Citations -  5565

Tim C. Diss is an academic researcher from University College London. The author has contributed to research in topics: Lymphoma & MALT lymphoma. The author has an hindex of 35, co-authored 52 publications receiving 5294 citations. Previous affiliations of Tim C. Diss include Guy's Hospital & University College Hospital.

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

TL;DR: IDH1 and IDH2 mutations represent the first common genetic abnormalities to be identified in conventional central and periosteal cartilaginous tumours and speculate that a mosaic pattern of IDH‐mutation‐bearing cells explains the reports of diverse tumours (gliomas, AML, multiple cartILaginous neoplasms, haemangiomas) occurring in the same patient.
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Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy

TL;DR: Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21), which results in a chimeric transcript between the AP12 and MLT genes.
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High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease.

TL;DR: Within a prospective cohort study on 60 HIV-infected patients with MCD, 14 patients developed KSHV/HHV8-associated non-Hodgkin lymphoma (NHL), which fell into 2 groups, suggesting different pathogenesis.
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Kaposi sarcoma–associated herpesvirus infects monotypic (IgMλ) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders

TL;DR: KSHV infects monotypic but polyclonal naive B cells and is associated with a range of lymphoproliferative disorders frompolyclonal isolated plasmablasts and microlymphomas to monoclonal microlyymphoma and frank plasmblastic lymphomas in MCD patients.
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Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10

TL;DR: CD10 is a phenotypic marker that specifically identifies the tumor cells in 90% of AITL, including the early cases, and provides an objective criterion for accurate and early diagnosis of A ITL.