T
Timo Lövgren
Researcher at University of Turku
Publications - 153
Citations - 8661
Timo Lövgren is an academic researcher from University of Turku. The author has contributed to research in topics: Fluorescence spectrometry & Immunoassay. The author has an hindex of 48, co-authored 153 publications receiving 8472 citations.
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Journal ArticleDOI
Europium as a label in time-resolved immunofluorometric assays
TL;DR: A nonisotopic immunoassay has been developed based on a sensitive detection of europium (III) in water solution using time-resolved fluorometry, using rabbit IgG as a model system.
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Europium Nanoparticles and Time-resolved Fluorescence for Ultrasensitive Detection of Prostate-specific Antigen
TL;DR: The universal streptavidin-coated europium(III) nanoparticle label is suitable for detection of any biotinylated molecule either in solution or on a solid phase.
Journal ArticleDOI
Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex
A. Katrukha,Anastasia V. Bereznikova,Tatiana V. Esakova,Kim Pettersson,Timo Lövgren,Maria E. Severina,Kari Pulkki,Liisa-Maria Vuopio-Pulkki,Nikolai B. Gusev +8 more
TL;DR: It is demonstrated that the main part of cTnI in serum collected from acute myocardial infarction patients is presented in the complex from CTnC, which results in a significant decrease of the interaction of mAbs with TnI.
Journal ArticleDOI
Degradation of cardiac troponin I: implication for reliable immunodetection
A. Katrukha,Anastasia V. Bereznikova,Vladimir L. Filatov,Tatiana V. Esakova,Olga V. Kolosova,Kim Pettersson,Timo Lövgren,Bulargina Tv,Igor R. Trifonov,Nikolai A. Gratsiansky,Kari Pulkki,L.-M. Voipio-Pulkki,Nikolai B. Gusev +12 more
TL;DR: Analysis of the proteolytic degradation of cardiac troponin I in human necrotic tissue and in serum concludes that antibodies selected for cTnI sandwich immunoassays should preferentially recognize epitopes located in the region resistant to proteolysis.
Journal ArticleDOI
Free and complexed prostate-specific antigen (PSA): in vitro stability, epitope map, and development of immunofluorometric assays for specific and sensitive detection of free PSA and PSA-alpha 1-antichymotrypsin complex.
Kim Pettersson,Timo Piironen,M Seppälä,L Liukkonen,Anders Christensson,Marja-Terttu Matikainen,M Suonpää,Timo Lövgren,Hans Lilja +8 more
TL;DR: The ease of calibration and the accuracy of free PSA assays in comparison with assays of the PSA-ACT complex suggest that measurements of free to total PSA most accurately reflect the inverse of the proportion of PSA complexed to ACT in serum.