T
Timo Stellfeld
Researcher at Bayer HealthCare Pharmaceuticals
Publications - 34
Citations - 844
Timo Stellfeld is an academic researcher from Bayer HealthCare Pharmaceuticals. The author has contributed to research in topics: Bombesin & Medicine. The author has an hindex of 14, co-authored 31 publications receiving 774 citations. Previous affiliations of Timo Stellfeld include Stanford University & Bayer Schering Pharma AG.
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Journal ArticleDOI
Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks.
Aileen Höhne,Linjing Mu,Michael Honer,P. August Schubiger,Simon M. Ametamey,Keith Graham,Timo Stellfeld,Sandra Borkowski,Dietmar Berndorff,Ulrich Klar,Ulrike Voigtmann,John E. Cyr,Matthias Friebe,Ludger Dinkelborg,Ananth Srinivasan +14 more
TL;DR: This study demonstrates the applicability of the silicon-based one-step n.c. radiolabeling method for the synthesis of new 18F-labeled bombesin derivatives for the PET imaging of GRPr expression in prostate tumor.
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Silicon‐Based Building Blocks for One‐Step 18F‐Radiolabeling of Peptides for PET Imaging
Linjing Mu,Aileen Höhne,P. August Schubiger,Simon M. Ametamey,Keith Graham,John E. Cyr,Ludger Dinkelborg,Timo Stellfeld,Ananth Srinivasan,Ulrike Voigtmann,Ulrich Klar +10 more
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Direct One-Step18F-Labeling of Peptides via Nucleophilic Aromatic Substitution
Becaud Jessica,Linjing Mu,Mylène Karramkam,P. A. Schubiger,Simon M. Ametamey,Keith Graham,Timo Stellfeld,Lutz Lehmann,Sandra Borkowski,Dietmar Berndorff,Ludger Dinkelborg,Ananth Srinivasan,René Smits,Beate Koksch +13 more
TL;DR: The results of the one-step [18F]-fluorination of tetrapeptides and bombesin peptides show that the direct 18F-labeling of peptides is feasible under mild conditions and in good radiochemical yields.
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18F-Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts
Linjing Mu,Cindy R. Fischer,Jason P. Holland,Becaud Jessica,P. August Schubiger,Roger Schibli,Simon M. Ametamey,Keith Graham,Timo Stellfeld,Ludger Dinkelborg,Lutz Lehmann +10 more
TL;DR: A new method for the 18F-radiolabeling of aromatic compounds based on the aromatic nucleophilic substitution (SNAr) reaction using triarylsulfonium salts has been developed and indicates that sulfonium ions have the potential to be optimized for labeling nonactivated and deactivated aryl rings that have Hammett σP substituent constants greater than –0.170.
Journal ArticleDOI
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) for the Protein Lysine Methyltransferase Smyd2.
Erik Eggert,Roman C. Hillig,Silke Koehr,Detlef Stöckigt,Jörg Weiske,Naomi Barak,Jeffrey Mowat,Thomas Brumby,Clara D. Christ,Antonius Ter Laak,Tina Lang,Amaury Ernesto Fernandez-Montalvan,Volker Badock,Hilmar Weinmann,Ingo Hartung,Dalia Barsyte-Lovejoy,Magdalena M. Szewczyk,Steven Kennedy,Fengling Li,Masoud Vedadi,Masoud Vedadi,Peter Brown,Vijayaratnam Santhakumar,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Timo Stellfeld,Carlo Stresemann +26 more
TL;DR: The development of a potent, selective, and cell-active, substrate-competitive inhibitor of SMYD2 is reported, which is the first reported inhibitor suitable for in vivo target validation studies in rodents.