Showing papers in "European Journal of Organic Chemistry in 2012"

TL;DR: In this paper, the fundamental reactions for C-C single bond activation and cleavage mediated by transition metal complexes are reviewed in terms of their mechanisms, their intrinsic problems, and their published examples.

TL;DR: In this paper, a series of 1,1- dicyano-4-[4-(diethylamino)phenyl]buta-1,3-dienes were synthesized and the number and position of additional CN substituents along the 1, 1-dicyanobuta 1,3dienyl fragment was systematically varied.

TL;DR: Recent advances in the field of oxidative carbonylation reactions leading to carbonylated heterocyclic derivatives are presented in this paper, covering from 2006 to the beginning of 2012.

TL;DR: A figure of merit (FM) was developed by normalizing the 2PA action cross-section, a commonly used parameter for characterizing bioimaging 2PF probes, by the photodecomposition quantum yield to provide a more comprehensive comparison of fluorophores for 2PFBioimaging.

TL;DR: A review of 5-monosubstituted tetrazoles can be found in this paper, where the authors focus on the preparation and further functionalization of these heterocycles.

TL;DR: In this article, the authors present a minireview of the development of transition-metal-catalyzed trifluoromethylation of arene substrates under mild reaction conditions.

TL;DR: The entire saga of dienamine chemistry from “preformed dienamines” to “in situ dienines” and its applications in the synthesis of bioactive molecules and natural products are discussed.

TL;DR: The introduction of a perfluoroalkyl group, with emphasis on the trifluoromethyl moiety, is a challenging topic as mentioned in this paper, however, a renaissance of this chemistry has happened thanks to reports both of numerous new reagents (stable, easy to handle and to prepare) and of easier preparation of older reagents.

TL;DR: An overview of recent advances in the field of asymmetric IMCRs with a focus on stereoselective α-additions of isocyanides is given and future opportunities and potential applications of (asymmetric) IM CRs are briefly discussed.

TL;DR: In this paper, the authors present evidence that the privileged use of the 3,5-bis trifluoromethyl group in thiourea organocatalysis is due to the involvement of the ortho-CH bond in the binding event with Lewis-basic sites.

TL;DR: A brief review of radical ion chemistry can be found in this article, where the use of transition metal photocatalysis is used as a convenient means to investigate radical ion-mediated transformations.

TL;DR: In 2012, the 125th anniversary of the unique molecule Troger's base (TB), first synthesized by Julius Troger in 1887, was celebrated in this article, which led to increasing interest in the development of synthetic methodology for TB analogues initially for applications in the field of molecular recognition.

TL;DR: In this article, the authors acknowledge the ISO of the Universidad de Alicante for a grant from the Spanish Ministerio de Ciencia e Innovación (MICINN) (grant numbers CTQ2007-65218, CTQ2011-24151) and Consolider Ingenio (Grant number 2010-CSD2007-00006), the Generalitat Valenciana (GRANT number PROMETEO/2009/039), and Fondos Europeos para el Desarrollo Regional (FEDER).

TL;DR: There have been a number of reports from several research groups demonstrating advances in several neglected areas of oxidative coupling, and this microreview summarizes these new advances and provides an overview of recent natural product syntheses that showcase the power of these transformations.

TL;DR: In this paper, the indolo-sesquiterpenes dixiamycins A (1) and B (2), oxiamycin (3), chloroxiamycan (4) and chloroxianine (5) were isolated from a marine-derived Actinomycete and characterized.

TL;DR: In this paper, a highly efficient, chemically stable, and well defined homogeneous silver(I) catalyst is reported for the cycloaddition of azides onto terminal alkynes (Ag-AAC reaction).

TL;DR: In this paper, a review summarizes the recent progress in this area and covers new applications in the field of Ritter-type and multicomponent reactions, including catalytic versions for the development of more eco-friendly synthetic routes to amides.

TL;DR: The potential of nitrile oxide/alkyne cycloaddition (NOAC) as a covalent conjugation tool for nucleic acid chemistry and materials science is evaluated and the case for a prominent position for Nitrile oxides in the catalyst-free bioconjugation toolbox is presented.

TL;DR: In this article, a combination of Pd(OAc)2 and XPhos (2-dicyclohexylphosphanyl-2′,4′,6′-triisopropylbiphenyl) was used for Suzuki coupling of heteroaryl chlorides and tosylates at room temperature.

TL;DR: An overview of the chemical and pharmacological potential of European Euphorbia species is provided and the main aspects of the development of ingenol 3-angelate as a drug, screening methods, isolation strategies, the chemical characteristics of Euphorbiaceae diterpenes and the results of pharmacological investigations are surveyed.

TL;DR: This review presents the methods currently used to access molecules of this class in a stereoselective manner, including manipulation of the flavone/flavanone core, carbon-carbon bond formation, and carbon-heteroatom bond formation.

TL;DR: A series of mono-to hexachlorinated BODIPY dyes have been prepared in good to excellent yields through the use of N-chlorosuccinimide as an inexpensive halogenating reagent as discussed by the authors.

TL;DR: In this paper, 13 new, stable, push-pull systems featuring dimethylamino and pyrazine-2,3-dicarbonitrile moieties as the donor and acceptor, respectively, and systematically extended and varied π-linkers were prepared and investigated.

TL;DR: In this paper, a plausible reaction mechanism is proposed to account for the cyclization reaction of substituted acetophenones with diphenylacetylene in the presence of [RuCl2(p-cymene)2] (2 mol-%), AgSbF6 (8 mol-%) and Cu(OAc)2·H2O (25 mol-%).

TL;DR: Two principal biocatalytic approaches to the Henry (nitroaldol) reaction are described, including a direct enzyme-catalysed carbon–carbon bond formation resulting in either an enantio-enriched or enantiopure β-nitro alcohol.

TL;DR: It was shown that a His-tagged recombinant transaminase from Vibrio fluvialis showed for a single substrate, ethyl acetoacetate, significantly higher stereoselectivity for the amination compared to the corresponding commercial enzyme preparation.

TL;DR: In this paper, the authors reported the construction of spiro compounds through cascade double Michael reactions between divinyl ketones and N-unprotectedoxindoles or N-phenyl-protected pyrazolones catalyzed by a combination of the easily available 9-amino-9-deoxy-epi-quinine with N-Boc-D -phenylglycine.

TL;DR: In this article, a review of recent developments in the chemistry of ketenimines is presented, demonstrating that heterocumulenes of this class are versatile reactive intermediates in the synthesis of nitrogenated heterocycles.

TL;DR: In this article, a phytochemical investigation of aquilariae lignum resinatum, the resinous wood of Aquilaria sinensis (Lour.) Gilg, led to the isolation of nine new 2-(2-phenylethyl)chromone derivatives, aquilarones A-I (1, 9), together with two known analogues (10 and 11).

TL;DR: A new two-step hydride mechanism for the MAO-catalysed oxidative deamination of amines is proposed that is in agreement with available experimental data and provided evidence against both traditional polar nucleophilic and single-electron radical pathways.