T
Timothy A. Hoover
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 23
Citations - 1338
Timothy A. Hoover is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Bacillus anthracis & Coxiella burnetii. The author has an hindex of 18, co-authored 23 publications receiving 1275 citations. Previous affiliations of Timothy A. Hoover include United States Department of the Army.
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Dendritic Cell Targeting of Bacillus anthracis Protective Antigen Expressed by Lactobacillus acidophilus Protects Mice from Lethal Challenge
TL;DR: Development of this strategy for oral delivery of DC-targeted antigens provides a safe and protective vaccine via a bacterial adjuvant that may potentiate mucosal immune responses against deadly pathogens.
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A Coxiella burnetti repeated DNA element resembling a bacterial insertion sequence.
TL;DR: A DNA fragment located on the 3' side of the Coxiella burnetii htpAB operon was determined by Southern blotting to exist in approximately 19 copies in the Nine Mile I genome and several features characteristic of bacterial insertion sequences were discovered.
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Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis
Katherine C. Brittingham,Gordon Ruthel,Rekha G. Panchal,Claudette L. Fuller,Wilson J. Ribot,Timothy A. Hoover,Howard A. Young,Arthur O. Anderson,Sina Bavari +8 more
TL;DR: It is found that human DCs readily engulfed fully pathogenic Ames and attenuated B. anthracis spores predominately by coiling phagocytosis, suggesting that B. Anthracis may exploit DCs to facilitate infection.
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Chromosomal DNA Deletions Explain Phenotypic Characteristics of Two Antigenic Variants, Phase II and RSA 514 (Crazy), of the Coxiella burnetii Nine Mile Strain†
Timothy A. Hoover,D. W. Culp,Michael H. Vodkin,Jim C. Williams,Herbert A. Thompson,Herbert A. Thompson +5 more
TL;DR: Basic alignment and homology studies indicated that a large group of LPS biosynthetic genes, arranged in an apparent O-antigen cluster, was deleted in both variants.
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Time-lapse confocal imaging of development of Bacillus anthracis in macrophages.
TL;DR: Time-lapse confocal microscopy is used to follow individual fluorescent spores over time and it is determined that some phagocytized spores survive beyond germination, to become bacilli that then replicate within the macrophages.