T
Timothy Hubbell
Researcher at University of Cincinnati
Publications - 9
Citations - 461
Timothy Hubbell is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Fatty acid & Fatty acid-binding protein. The author has an hindex of 8, co-authored 9 publications receiving 459 citations. Previous affiliations of Timothy Hubbell include Texas A&M University.
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Journal ArticleDOI
Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins.
TL;DR: The lack of fluorescence self-quenching upon binding 2 mol of either trans- or cis-parinaric acid/mol L-FABP is consistent with the presence of two binding sites with dissimilar orientation in the L- FABP, which predicts a structurally different binding site or sites.
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Fatty Acid Binding Protein: Stimulation of Microsomal Phosphatidic Acid Formation
TL;DR: Results demonstrate for the first time that both L-F ABP and I-FABP stimulate liver microsomal phosphatidic acid formation by enhancing synthesis of phosphatidate from fatty acyl-CoA and glycerol 3-phosphate.
Journal ArticleDOI
Recombinant liver fatty acid binding protein interacts with fatty acyl-coenzyme A.
TL;DR: In this study, highly pure recombinant L-FABP and I-F ABP were used first to establish binding to fatty acyl-CoAs and then to examine the effects of these FABPs on microsomal phosphatidic acid synthesis.
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Expression of rat L-FABP in mouse fibroblasts: role in fat absorption
Friedhelm Schroeder,John R. Jefferson,David M. Powell,Sandra Incerpi,Judith K. Woodford,S. M. Colles,S. Myers-Payne,T. Emge,Timothy Hubbell,D. Moncecchi,Daniel R. Prows,Clayton E. Heyliger +11 more
TL;DR: For the first time in intact cells, L-FABP, a protein most prevalent in liver and intestine where much fat absorption takes place, may have a role in fatty acid and cholesterol absorption and the level of cytosolic fatty acids in intactcells is shown to regulate both the extent and specificity of fatty acid uptake.
Journal ArticleDOI
Isolation and characterization of two fatty acid binding proteins from mouse brain
Sean C. Myers-Payne,Timothy Hubbell,Lixia Pu,Frank Schnütgen,Torsten Börchers,W. Gibson Wood,Friedrich Spener,Friedhelm Schroeder +7 more
TL;DR: Oleate competition binding indicated that the two brain FABPs had distinct ligand binding specificities, although both preferentially bound unsaturated fatty acids, twofold differences in specific saturated fatty acid binding were observed.