T
Timothy J. Holmes
Researcher at Rensselaer Polytechnic Institute
Publications - 38
Citations - 959
Timothy J. Holmes is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Deconvolution & Iterative reconstruction. The author has an hindex of 14, co-authored 38 publications receiving 944 citations. Previous affiliations of Timothy J. Holmes include New York State Department of Health.
Papers
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Journal ArticleDOI
Blind deconvolution of quantum-limited incoherent imagery: maximum-likelihood approach
TL;DR: In this paper, a blind deconvolution approach for wide field and confocal fluorescence microscopy is presented. But the impulse response of the system is assumed to be unknown.
Book ChapterDOI
Light Microscopic Images Reconstructed by Maximum Likelihood Deconvolution
Timothy J. Holmes,Timothy J. Holmes,Santosh Bhattacharyya,Joshua Cooper,David K. Hanzel,Vijaykumar Krishnamurthi,Wen-Chieh Lin,Wen-Chieh Lin,Badrinath Roysam,Badrinath Roysam,Donald H. Szarowski,James N. Turner,James N. Turner +12 more
TL;DR: The main purpose of this chapter is to introduce the reader to the methodology of maximum likelihood (ML)-based deblurring algorithms, aimed at the interdisciplinary scientist who needs to understand the main principles behind the algorithms used.
Journal ArticleDOI
Cutaneous-evoked tinnitus. I. Phenomenology, psychophysics and functional imaging.
Anthony T. Cacace,Joseph P. Cousins,Steven M. Parnes,David Semenoff,Timothy J. Holmes,Dennis J. McFarland,Charles Davenport,Keith Stegbauer,Thomas J. Lovely +8 more
TL;DR: The phenomenology of this discovery is focused on, which provides perceptual correlates using contemporary psychophysical methods and document in one individual cutaneous-evoked tinnitus-related neural activity using functional magnetic resonance imaging.
Journal ArticleDOI
Automated Three-Dimensional Tracing of Neurons in Confocal and Brightfield Images
Wenyun He,Thomas A. Hamilton,Andrew R. Cohen,Timothy J. Holmes,Christopher Pace,Donald H. Szarowski,James N. Turner,Badrinath Roysam +7 more
TL;DR: An improved algorithm for adaptive 3-D skeletonization of noisy images enables the tracing of dye-injected neurons imaging by fluorescence confocal microscopy and HRP-stained neurons imaged by transmitted-light brightfield microscopy.
Journal ArticleDOI
Cutaneous-evoked tinnitus. II. Review Of neuroanatomical, physiological and functional imaging studies.
Anthony T. Cacace,Joseph P. Cousins,Steven M. Parnes,Dennis J. McFarland,David Semenoff,Timothy J. Holmes,Charles Davenport,Keith Stegbauer,Thomas J. Lovely +8 more
TL;DR: A neuroscience framework that encompasses several distinct areas of research is used to conceptualize and help understandCutaneous-evoked tinnitus and the role of functional imaging modalities in studying various phantom perceptions is considered.