T
Timothy P. Garrington
Researcher at University of Colorado Denver
Publications - 49
Citations - 2953
Timothy P. Garrington is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Kinase & MAP kinase kinase kinase. The author has an hindex of 18, co-authored 46 publications receiving 2687 citations. Previous affiliations of Timothy P. Garrington include University of Milano-Bicocca & Boston Children's Hospital.
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Journal ArticleDOI
Organization and regulation of mitogen-activated protein kinase signaling pathways
TL;DR: The recent elucidation of scaffolding mechanisms for MAPK pathways has begun to solve the puzzle of how specificity in signaling can be achieved for each MAPK pathway in different cell types and in response to different stimuli.
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Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis
Franco Locatelli,Michael B. Jordan,Carl E. Allen,Simone Cesaro,Carmelo Rizzari,Anupama Rao,Barbara A. Degar,Timothy P. Garrington,Julián Sevilla,Maria-Caterina Putti,Franca Fagioli,Martina Ahlmann,Jose-Luis Dapena Diaz,Michael J Henry,Fabrizio De Benedetti,Alexei Grom,Geneviève Lapeyre,Philippe Jacqmin,Maria Ballabio,Cristina de Min +19 more
TL;DR: Empalumab was an efficacious targeted therapy for patients with primary hemophagocytic lymphohistiocytosis and was not associated with any organ toxicity.
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Reovirus-induced apoptosis is mediated by TRAIL.
Penny Clarke,Suzanne M. Meintzer,Spencer B. Gibson,Christian Widmann,Timothy P. Garrington,Gary L. Johnson,Kenneth L. Tyler +6 more
TL;DR: It is proposed that reovirus infection promotes apoptosis via the expression of DR5 and the release of TRAIL from infected cells and Virus-induced regulation of the TRAIL apoptotic pathway defines a novel mechanism for virus-induced apoptosis.
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MEKK2 Associates with the Adapter Protein Lad/RIBP and Regulates the MEK5-BMK1/ERK5 Pathway *
Weiyong Sun,Kamala Kesavan,Brian C. Schaefer,Timothy P. Garrington,Margaret F. Ware,Nancy Lassignal Johnson,Erwin W. Gelfand,Gary L. Johnson +7 more
TL;DR: By yeast two-hybrid library screening, MEK5, the MAPK kinase in the big mitogen-activated protein kinase 1 (BMK1)/ERK5 pathway, is identified as a binding partner for MEKK2, demonstrating cotranslocation of MEKK 2 and Lad/RIBP during T cell activation.
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MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.
Toshiaki Yujiri,Gary R. Fanger,Timothy P. Garrington,Thomas K. Schlesinger,Spencer B. Gibson,Gary L. Johnson +5 more
TL;DR: MEKK1 activation can protect cells from apoptosis in response to change in the integrity of the microtubule cytoskeleton, demonstrating a specific role of MEKK1 in this response.