T
Ting-Chao Chou
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 244
Citations - 23898
Ting-Chao Chou is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Virus & In vivo. The author has an hindex of 57, co-authored 240 publications receiving 22257 citations. Previous affiliations of Ting-Chao Chou include Kettering University & Albert Einstein College of Medicine.
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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Ting-Chao Chou,Paul Talalay +1 more
TL;DR: A generalized method for analyzing the effects of multiple drugs and for determining summation, synergism and antagonism has been proposed and has been used to analyze experimental data obtained from enzymatic, cellular and animal systems.
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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
TL;DR: This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination studies, in terms of experimental design, data acquisition, data interpretation, and computerized simulation.
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Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.
Timothy W. Baba,Vladimir Liska,Regina Hofmann-Lehmann,Josef Vlasak,Weidong Xu,Seyoum Ayehunie,Lisa A. Cavacini,Marshall R. Posner,Hermann Katinger,Gabriela Stiegler,Bruce J. Bernacky,Tahir A. Rizvi,Russell D. Schmidt,Lorraine R Hill,Michale E. Keeling,Yichen Lu,Joel E. Wright,Ting-Chao Chou,Ruth M. Ruprecht +18 more
TL;DR: It is concluded that epitopes recognized by the three monoclonal antibodies are important determinants for achieving substantial protection, thus providing a rational basis for AIDS vaccine development.
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Analysis of combined drug effects: a new look at a very old problem
Ting-Chao Chou,Paul Talalay +1 more
TL;DR: The proposed method (median-effect plot) suffers from fewer restrictions and is more widely applicable than the isobologram or the fractional product method and provides insight into the nature of the dose-effect relationship with relatively few measurements.
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Computerized Quantitation of Synergism and Antagonism of Taxol, Topotecan, and Cisplatin Against Human Teratocarcinoma Cell Growth: a Rational Approach to Clinical Protocol Design
TL;DR: The findings suggest that, as a result of synergy, the doses of these agents needed to achieve an antitumor effect may be reduced by twofold to eightfold when these agents are given in combination.