Ting Y. Yu

TL;DR: PITX2 mRNA modulates atrial resting membrane potential and thereby alters the effectiveness of Na-channel blockers and may provide novel targets for antiarrhythmic drug development and companion therapeutics in AF.

TL;DR: ElectroMap is presented, an adaptable, high-throughput, open-source software for processing, analysis and mapping of complex electrophysiology datasets from diverse experimental models and acquisition modalities, employing multiple methodologies currently not widely available to researchers.

TL;DR: Experimental data suggest that preload reduction may be a simple and effective intervention to prevent disease progression and ventricular arrhythmias in ARVC and the design of the first controlled trial of preload-reducing therapy in patients with ARVC is described.

TL;DR: The murine LAPW myocardium has a different electrical phenotype and ion channel mRNA expression profile compared with other regions of the LA, and this is associated with increased ectopic activity.

TL;DR: A new optical mapping system for quantification of electrical activation and repolarisation in murine atria that reliably describes activation sequences, identifies areas of functional block, and allows quantifying of conduction velocities and vectors is developed and validated.