Showing papers in "Journal of the American College of Cardiology in 2016"

TL;DR: Jonathan L. Halperin, MD, FACC, FAHA, Chair Glenn N. Levine, MD; Sana M. Al-Khatib,MD; and Lesley H. Curtis, PhD, PhD are the current members of the FACC/FAHA Board of Directors.

TL;DR: It is confirmed that exercise-based CR reduces cardiovascular mortality and provides important data showing reductions in hospital admissions and improvements in quality of life.

TL;DR: Jonathan L. Halperin, MD, FACC, FAHA, Chair Glenn N. Levine, PhD, RN,FAHA, Immediate Past Chair, and Kim K. Birtcher, PharmD, MS, AACC, Chair-Elect.

TL;DR: In an analysis of participants with serial lipid measurements over many years, FH mutation carriers had higher cumulative exposure to LDL cholesterol than noncarriers and within any stratum of observed LDL cholesterol, risk of CAD was higher among FH mutations carriers than non carriers.

TL;DR: Statin-associated symptoms are important because they prompt dose reduction or discontinuation of these life-saving mediations, and management of SAS requires making the possible diagnosis, altering or discontinuing the statin treatment, and using alternative lipid-lowering therapy.

TL;DR: Halperin et al. as discussed by the authors, MD, FACC, FAHA, Chair, Chair elect, Chair-Elect, Chairperson, Chair of FAHA, Chair-elect.

TL;DR: This work was supported by a grant from the National Institutes of Health (NIH) and a collection of donations made by the public and private sectors.

TL;DR: Simple risk scores of baseline clinical variables may be useful to predict risks for ischemic and bleeding events after PCI with DES, thereby facilitating clinical decisions surrounding the optimal duration of DAPT.

TL;DR: Infarct size, measured within 1 month after primary PCI, is strongly associated with all-cause mortality and hospitalization for HF within 1 year and may, therefore, be useful as an endpoint in clinical trials and as an important prognostic measure when caring for patients with STEMI.

TL;DR: A novel cardiac biomarker staging system is reported that enables risk stratification in an era of emerging treatment strategies and reports a natural history of ATTRwt that is poor and the predictors of survival are poor.

TL;DR: The authors summarize the current understanding of lncRNA functions and their role as biomarkers in cardiovascular diseases.

TL;DR: Current and novel approaches to the diagnosis and treatment of cardiac amyloidosis are discussed, with particular reference to AL amyloidsosis in the heart.

TL;DR: The aim of this review is to provide a comprehensive contemporary update of SCAD to aid health care professionals in managing these patients in both the acute and chronic settings.

TL;DR: The frequency of off-label NOAC doses among AF patients and the associations between off- label dose therapy and clinical outcomes in community practice are assessed.

TL;DR: An introduction to miRNA biology and research methodology is provided, and advances in cardiovascular research to date are highlighted, including the potential of miRNAs as therapeutic targets in cardiac and vascular disease, and their use as novel biomarkers.

TL;DR: Conditions predisposing to SCD in sports demonstrate a significant age predilection, and the strong association of ARVC and left ventricular fibrosis with exercise-induced SCD reinforces the need for early detection and abstinence from intense exercise.

TL;DR: Both coronary artery bypass surgery and percutaneous intervention have been used to treat Kawasaki disease patients who develop myocardial ischemia as a consequence of coronary artery aneurysms and stenosis.

TL;DR: Assessment of myocardial fibrosis predicts both risk of sudden cardiac death and likelihood of LV functional recovery, and has significant potential to guide patient selection for cardioverter-defibrillator implantation.

TL;DR: In patients with acute symptoms, mapping techniques provide a useful tool for confirming or rejecting the diagnosis of myocarditis and are superior to the LLC, however, only T2 mapping has acceptable diagnostic performance in patients with chronic symptoms.

TL;DR: The hypothesis that individual differences in the intensity of the post-AMI inflammatory response, involving 1 or more inflammatory-modulating pathways, may contribute to adverse LV remodeling is reviewed, outlining how individual variations in the inflammatory response could provide important novel therapeutic targets and strategies.

TL;DR: BHV thrombosis provides a substrate for subsequent thromboembolism and may identify a reversible cause of prosthesis dysfunction, and the pathophysiological mechanisms that may lead to valve thrombus formation are discussed.

TL;DR: This randomized study showed that both after a single procedure and after redo procedures in patients with LSPAF, empirical electrical isolation of the LAA improved long-term freedom from atrial arrhythmias without increasing complications.

TL;DR: Alongside other established clinical risk factors, procedural complexity is an important parameter to take into account in tailoring upfront duration of DAPT.

TL;DR: In this article, the authors demonstrate the association between truncating mutations in the Filamin C (FLNC) gene and the development of high-risk dilated and arrhythmogenic cardiomyopathies.

TL;DR: The 12-month incidence of ScT reached 3% and could be significantly reduced when an optimized implantation strategy was employed, an effect that remained significant when adjusted for multivariable propensity score.

TL;DR: The finding that early CTO PCI in the left anterior descending coronary artery subgroup was beneficial warrants further investigation, and the overall benefit for CTOPCI in terms of LVEF or LVEDV was not found in patients with STEMI and concurrent CTO.

TL;DR: Among stable patients with prior MI, those with concomitant PAD have heightened ischemic risk, and ticagrelor reduced MACE, with a large absolute risk reduction, and MALE, and the 60-mg dose had particularly favorable outcomes for CV and all-cause mortality.

TL;DR: In the THAOS registry, ATTR in the United States is overwhelmingly a disorder of older adult male subjects with a cardiac-predominant phenotype, and neurologic phenotypic expression differs between wild-type disease and Val122Ile, but survival from enrollment in ThAOS does not.

TL;DR: In this paper, the authors assessed the incidence, potential predictors, and clinical implications of transcatheter heart valve thrombosis as determined by contrastenhanced multidetector computed tomography (MDCT) after TAVR.

TL;DR: Patients with severe aortic stenosis at increased risk for surgery had improved 3-year clinical outcomes after TAVR compared with surgery, and aorti valve hemodynamics were more favorable in TAVr patients without differences in structural valve deterioration.