Tobias Gerhard

TL;DR: In a US national cohort of adults with schizophrenia, excess deaths from cardiovascular and respiratory diseases implicate modifiable cardiovascular risk factors, including especially tobacco use, which highlight threats posed by substance abuse.

TL;DR: Challenges for health care systems, regulators, and policymakers include developing the evidence base on comparative risks and benefits; defining measures of treatment quality; and implementing policies that encourage evidence-based practices while avoiding unduly burdensome restrictions.

TL;DR: The data suggest that the risk of mortality with these drugs is generally increased with higher doses and seems to be highest for haloperidol and least for quetiapine, reinforcing the concept that they should be used in the absence of clear need.

TL;DR: Atypical antipsychotic medications are increasingly used for a wide range of clinical indications in diverse populations, including privately and publicly insured youth and elderly nursing home residents as discussed by the authors, which heighten policy challenges for payers, pa- tients, and clinicians related to appropriate prescribing and management, patient safety, and clinical effectiveness.

TL;DR: This article takes the incident user design as a reasonable default strategy because it reduces biases that can impact non‐randomized studies, especially when investigators use healthcare databases.