Showing papers by "Toby J. Gibson published in 1998"
TL;DR: The Clustal series of programs as mentioned in this paper have been widely used for multiple alignment and for preparing phylogenetic trees, and the most popular of these programs is the Clusteral W 1.7.
2,682 citations
TL;DR: Data suggest that Fish, which has five SH3 domains and a recently discovered phox homology (PX) domain, is involved in signalling by tyrosine kinases, and imply a specialized role in the actin cytoskeleton.
Abstract: We describe a method for identifying tyrosine kinase substrates using anti-phosphotyrosine antibodies to screen tyrosine-phosphorylated cDNA expression libraries. Several potential Src substrates were identified including Fish, which has five SH3 domains and a recently discovered phox homology (PX) domain. Fish is tyrosine-phosphorylated in Src-transformed fibroblasts (suggesting that it is a target of Src in vivo) and in normal cells following treatment with several growth factors. Treatment of cells with cytochalasin D also resulted in rapid tyrosine phosphorylation of Fish, concomitant with activation of Src. These data suggest that Fish is involved in signalling by tyrosine kinases, and imply a specialized role in the actin cytoskeleton.
173 citations
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical properties of E.R. A. Meltzer's Hoyskolefond.
165 citations
TL;DR: The argument is developed by first considering some relevant properties of three disparate multigene families encoding proteins belonging to the KH domain, SRC and HOX groups, and then draw some general conclusions.
120 citations