T
Todd A. Gillespie
Researcher at Eli Lilly and Company
Publications - 11
Citations - 681
Todd A. Gillespie is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Xanomeline & Agonist. The author has an hindex of 7, co-authored 11 publications receiving 661 citations.
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Journal ArticleDOI
Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry.
Sheerin Khatib-Shahidi,Malin Andersson,Jennifer L. Herman,Todd A. Gillespie,Richard M. Caprioli +4 more
TL;DR: IMS analysis of tissues from 8 mg/kg olanzapine dosed rats revealed temporal distribution of the drug and metabolites that correlate to previous quantitative whole- body autoradiography studies, and Whole-body MALDI IMS is further extended to detecting proteins from organs present in a whole-body sagittal tissue section.
Journal ArticleDOI
Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection.
John T. Catlow,Richard D. Barton,Matt Clements,Todd A. Gillespie,Michael Goodwin,Steven P. Swanson +5 more
TL;DR: The HPLC-ED method compared favorably with a negative chemical ionization GC-MS method previously utilized for analysis of olanzapine in human plasma and was applied to human plasma samples from human clinical trials with olanZapine.
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Mass spectrometry for small molecule pharmaceutical product development: a review.
TL;DR: This review describes a multi-tiered MS strategy designed to enhance and accelerate the identification and profiling of both process- and degradation-related impurities in either the active pharmaceutical ingredient (API) or formulated product.
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Determination of xanomeline in human plasma by ionspray tandem mass spectrometry
TL;DR: A fast, sensitive and specific assay has been developed to determine xanomeline plasma concentrations using ion-spray tandem mass spectrometry.
Journal ArticleDOI
Identification and counting of carbonyl and hydroxyl functionalities in protonated bifunctional analytes by using solution derivatization prior to mass spectrometric analysis via ion-molecule reactions
TL;DR: A mass spectrometric method has been developed for the identification of carbonyl and hydroxylfunctional groups, as well as for counting the functional groups, in previously unknown protonated bifunctional oxygen-containing analytes.