Journal ArticleDOI
Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection.
John T. Catlow,Richard D. Barton,Matt Clements,Todd A. Gillespie,Michael Goodwin,Steven P. Swanson +5 more
TLDR
The HPLC-ED method compared favorably with a negative chemical ionization GC-MS method previously utilized for analysis of olanzapine in human plasma and was applied to human plasma samples from human clinical trials with olanZapine.About:
This article is published in Journal of Chromatography B: Biomedical Sciences and Applications.The article was published on 1995-06-09. It has received 100 citations till now. The article focuses on the topics: Ascorbic acid & Detection limit.read more
Citations
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Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder
Robert M. Bilder,Robert Goldman,Jan Volavka,Pál Czobor,Matthew J. Hoptman,Brian Sheitman,Jean Pierre Lindenmayer,Leslie Citrome,Joseph P. McEvoy,Michal Kunz,Miranda Chakos,Thomas B. Cooper,Terri L. Horowitz,Jeffrey A. Lieberman +13 more
TL;DR: Patients with a history of suboptimal response to conventional treatments may show cognitive benefits from newer antipsychotic drugs, and there may be differences between atypical antipsychotics drugs in their patterns of cognitive effects.
Journal Article
Disposition and Biotransformation of the Antipsychotic Agent Olanzapine in Humans
K. Kassahun,Edward L. Mattiuz,E. H. Nyhart,Obermeyer B,Todd A. Gillespie,Anthony T. Murphy,Goodwin Rm,Tupper D,J. T. Callaghan,Lemberger L +9 more
TL;DR: OLZ was extensively metabolized in humans via N-glucuronidation, allylic hydroxylation, N-oxidation, N -dealkylation and a combination thereof, andSemiquantitative data obtained from plasma samples from subjects given [14C]OLZ suggest that the main circulating metabolite is 10-N-glUCuronide.
Journal ArticleDOI
Adjunctive high-dose glycine in the treatment of schizophrenia.
Daniel C. Javitt,Daniel C. Javitt,Daniel C. Javitt,Gail Silipo,Angel Cienfuegos,Anne Marie Shelley,Nigel Bark,Mohan Park,Jean-Pierre Lindenmayer,Ray Suckow,Stephen R. Zukin +10 more
TL;DR: This study evaluated the degree to which symptom improvements might be related to alterations in antipsychotic drug levels in an additional group of 12 subjects and found that glycine treatment was associated with an 8-fold increase in serum glycine levels, similar to that observed previously.
Journal ArticleDOI
A PET study of 5-HT2 and D2 dopamine receptor occupancy induced by olanzapine in healthy subjects.
TL;DR: Extrapolation from the present observations after a 10 mg single-dose suggest, that at the lower end of the clinically examined dose range the D2 and 5-HT2 receptor occupancy should be similar to that induced by standard doses of clozapine.
Journal ArticleDOI
Olanzapine plasma concentrations and clinical response: acute phase results of the North American Olanzapine Trial.
TL;DR: A receiver operating characteristic (ROC) curve analysis of 12-hour olanzapine concentrations and treatment response from the North American Double-Blind Olanzapine Trial found a 12- hour olanZapine plasma concentration of >23.2 ng/mL was a predictor of therapeutic response in acutely ill patients with schizophrenia.
References
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Journal Article
The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.
TL;DR: It is predicted that olanzapine will have an atypical profile and will be less likely to induce undesirable extrapyramidal symptoms than currently available drugs.
Journal ArticleDOI
Isolation of Acidic, Neutral, and Basic Drugs from Whole Blood Using A Single Mixed-Mode Solid-Phase Extraction Column
TL;DR: A solid-phase extraction procedure was developed for the isolation of acidic, neutral, and basic drugs from whole blood and the drugs with pKa's close to the pH of the extraction system appeared in both fractions.
Related Papers (5)
Determination of olanzapine in serum by high-performance liquid chromatography using ultraviolet detection considering the easy oxidability of the compound and the presence of other psychotropic drugs
Ole V. Olesen,Kristian Linnet +1 more