Todd E. DeFor

TL;DR: Spontaneously produced and LPS-stimulated IL-10 levels were correlated with the development of transplant-related complications (TRC) including grade II–IV acute GVHD, veno-occlusive disease, idiopathic pneumonia syndrome and multi-organ dysfunction syndrome, and with death before day 100.

TL;DR: A regimen using fludarabine, cyclophosphamide, and anti‐thymocyte globulin followed by infusion of T‐cell depleted bone marrow or unmanipulated umbilical cord blood is developed to potentially reduce late effects of malignancy, chronic graft‐versus‐host disease (GVHD), endocrinopathy, and infertility in patients with Fanconi anemia undergoing HLA‐matched related donor hematopoietic cell transplantation.

TL;DR: CMV-seropositive alloBMT patients are at highest risk for CMV antigenemia and for organ disease as well, and intensive surveillance continuing for more than 6 months after BMT may be indicated.

TL;DR: Data suggest that chemotherapy-induced lymphodepletion enhances activation of donor lymphocytes, the toxicity needs to be managed before testing whether better disease control can be achieved.

TL;DR: The observations support development of donor NK cellular therapies for advanced NHL as a strategy to overcome chemoresistance andTherapeutic efficacy may be further improved through disruption of the immunosuppressive environment and infusion of exogenous IL-15.