M. Bigler

TL;DR: It is shown that chronic activation of both human and murine CD4+T cells in the presence of interleukin (IL)-10 gives rise to CD4-T-cell clones with low proliferative capacity, producing high levels ofIL-10, low levels of IL-2 and no IL-4.

TL;DR: Human CD4+ T cells, activated by allogeneic monocytes in a primary mixed lymphocyte reaction in the presence of exogenous interleukin 10, specifically failed to proliferate after restimulation with the same alloantigens, demonstrating that IL-10 induces T cell anergy and therefore may play an important role in the induction and maintenance of antigen-specific T cell tolerance.

TL;DR: Data indicate that high endogenous IL- 10 production is a general phenomenon in SCID patients in whom allogenic stem cell transplantation results in immunologic reconstitution and induction of tolerance.

TL;DR: The first characterization of human CD200R (hCD200R) is reported and its binding characteristics to hCD200 are defined, and two mCD200 receptor-like family members were shown to pair with the activatory adaptor protein, DAP12, suggesting that these receptors would transmit strong activating signals in contrast to the apparent inhibitory signal delivered by triggering the CD 200R.

TL;DR: It is reported that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8+ T cells when added concomitantly with the Ag in the presence of APC, and the generation of allospecific cytotoxic activity is inhibited byIL-10.