T
Tom Jacks
Researcher at Merck & Co.
Publications - 14
Citations - 934
Tom Jacks is an academic researcher from Merck & Co.. The author has contributed to research in topics: Growth hormone secretagogue & Growth hormone secretion. The author has an hindex of 12, co-authored 14 publications receiving 915 citations.
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Journal ArticleDOI
A nonpeptidyl growth hormone secretagogue
Roy G. Smith,Kang Cheng,William R. Schoen,Sheng-Shung Pong,Gerard J. Hickey,Tom Jacks,B. Butler,Wanda W.-S. Chan,L.-Y. Chaung,F Judith +9 more
TL;DR: The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Tr phe-Phe-Lys-NH2 (GHRP-6).
Journal Article
Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.
Roy G. Smith,Sheng-Shung Pong,G. J. Hickey,Tom Jacks,Kang Cheng,Reid J. Leonard,Charles J. Cohen,Joseph P. Arena,C. H. Chang,Drisko J,Matthew J. Wyvratt,M. H. Fisher,Ravi P. Nargund,Arthur A. Patchett +13 more
TL;DR: A GH secretagogue MK0677, is described, which synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).
Journal ArticleDOI
Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles
Tom Jacks,G. J. Hickey,F Judith,J. E. Taylor,Howard Y. Chen,D Krupa,William P. Feeney,William R. Schoen,D Ok,M. H. Fisher,Matthew J. Wyvratt,Roy G. Smith +11 more
TL;DR: When L-692,585 was administered once daily for 14 consecutive days at 0, 0.01 or 0.10 mg/kg to each of 6 dogs, peak plasma GH levels and total GH release on days 1, 8 and 15 significantly increased in a dose-dependent manner, and no desensitization was evident.
Journal ArticleDOI
Efficacy and specificity of L-692,429, a novel nonpeptidyl growth hormone secretagogue, in beagles.
Gerard J. Hickey,Tom Jacks,F Judith,J. E. Taylor,William R. Schoen,D Krupa,P Cunningham,John W. Clark,Roy G. Smith +8 more
TL;DR: It is demonstrated that L-692,429 is a novel nonpeptidyl secretagogue that stimulates a marked, but transient, increase in serum GH levels in the dog.
Journal ArticleDOI
Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles
G. J. Hickey,Tom Jacks,Klaus D. Schleim,Easter G. Frazier,Howard Y. Chen,D Krupa,William P. Feeney,Ravi P. Nargund,Arthur A. Patchett,Roy G. Smith +9 more
TL;DR: Chronic oral administration of MK-0677 was associated with significant increases in GH and IGF-I levels that were maintained for the duration of the treatment, suggesting that IGF-i mediated negative feedback on both the GH and cortisol axes prevents hyperstimulation of the GH axis by MK- 0677.