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Wanda W.-S. Chan
Researcher at Merck & Co.
Publications - 36
Citations - 2376
Wanda W.-S. Chan is an academic researcher from Merck & Co.. The author has contributed to research in topics: Growth hormone secretagogue & Secretagogue. The author has an hindex of 18, co-authored 36 publications receiving 2330 citations.
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Journal ArticleDOI
Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry
Susan P. Rohrer,Elizabeth T. Birzin,Ralph T. Mosley,Scott C. Berk,Steven M. Hutchins,Dong-Ming Shen,Yusheng Xiong,Edward C. Hayes,Rupa M. Parmar,Forrest Foor,Sudha W. Mitra,Sylvia J. Degrado,Min Shu,John M. Klopp,Sheng-Jian Cai,Allan D. Blake,Wanda W.-S. Chan,Alex Pasternak,Lihu Yang,Arthur A. Patchett,Roy G. Smith,Kevin T. Chapman,James M. Schaeffer +22 more
TL;DR: The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions, including inhibition of glucagon release from mouse pancreatic alpha cells and mediator of insulin secretion from pancreatic beta cells.
Journal ArticleDOI
A nonpeptidyl growth hormone secretagogue
Roy G. Smith,Kang Cheng,William R. Schoen,Sheng-Shung Pong,Gerard J. Hickey,Tom Jacks,B. Butler,Wanda W.-S. Chan,L.-Y. Chaung,F Judith +9 more
TL;DR: The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Tr phe-Phe-Lys-NH2 (GHRP-6).
Journal ArticleDOI
Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue
Arthur A. Patchett,Ravi P. Nargund,J R Tata,M H Chen,K J Barakat,D B Johnston,Kang Cheng,Wanda W.-S. Chan,B Butler,G. J. Hickey +9 more
TL;DR: A potent, orally active growth hormone (GH) secretagogue L-163,191 belonging to a recently synthesized structural class has been characterized and has been selected for clinical studies.
Journal ArticleDOI
The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3',5'-monophosphate accumulation in rat primary pituitary cell culture.
TL;DR: Results from this study indicate that GHRP-6 and GRF stimulated GH release from somatotrophs via different receptors and through discrete mechanisms.
Journal ArticleDOI
Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells.
TL;DR: The data suggest that the effects of GHRP-6 on GH release, either alone or together with GRF, are at least partially mediated via the activation of protein kinase-C.