Tom S. Miya

TL;DR: It is suggested that a threshold dose of cadmium must be exceeded in order to induce concentrations of metallothionein adequate to ameliorate acute Cadmium toxicity.

TL;DR: Inhibition of the metabolism of aminopyrine, hexobarbital, p-nitroanisole and zoxazolamine in microsomal subfractions obtained from these animals is reduced to 50% of control values by the cadmium treatment.

TL;DR: At the doses of cadmium used in this study histologic examination of liver indicated focal necrosis, hemorrhage, inflammation, and congestion in some treatment groups.

TL;DR: Tolerance to barbital cannot be ascribed to decreased drug absorption, to increased excretion of the drug, or to a decreased permeability of the blood-brain barrier.

TL;DR: Stimulation by chlordiazepoxide of ascorbic acid excretion, and the ability of dl -ethionine to block the drug-induced stimulation of liver weight, liver protein content, and hepatic N -demethylase activity, suggest that the mechanism of tolerance development involves stimulation of hepatic microsomal enzymes responsible for drug metabolism.