Journal ArticleDOI
Distribution and metabolism of barbital-14c in tolerant and nontolerant rats.
TLDR
Tolerance to barbital cannot be ascribed to decreased drug absorption, to increased excretion of the drug, or to a decreased permeability of the blood-brain barrier.About:
This article is published in Biochemical Pharmacology.The article was published on 1964-09-01. It has received 63 citations till now. The article focuses on the topics: Barbital.read more
Citations
More filters
Journal ArticleDOI
Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates.
Costas Ioannides,Dennis V. Parke +1 more
TL;DR: Barbitone is an effective inducer of the drug‐metabolizing enzymes, yet does not interact spectrally with cytochrome P‐450; this is in accord with the observations that although there are increases in NADPH‐cytochrome c reductase and cy tochrome b5, following administration of barbitone there is no increase in cyto Chrome P‐ 450.
Journal ArticleDOI
Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates
TL;DR: Mice treated with 6-hydroxydopamine before they were chronically fed phenobarbital did not develop functional barbiturate tolerance, measured by duration of the loss of righting reflex and hypothermia.
Journal ArticleDOI
Withdrawal in the rat after long-term forced oral barbital administration.
TL;DR: In 5 experiments a barbital solution was the sole drinking source for male rats and a positive correlation between the dose consumed and a pre-experimental hexobarbital threshold developed during the treatment.
Journal ArticleDOI
On the interaction of drugs with the cholinergic nervous system—III: Tolerance to phencyclidine derivatives: In vivo and in vitro studies
TL;DR: No measurable changes could be observed in the amount, the affinity towards diverse ligands or the kinetic properties of this enzyme, between naive, cyclohexamine-tolerant and physostigmine tolerant mice, and no measurable differences could be found in any of these parameters.
Journal ArticleDOI
On the interaction of drugs with the cholinergic nervous system. I. Tolerance to phencyclidine derivatives in mice: pharmacological characterization.
TL;DR: It was established that cyclohexamine is a better tolerance-inducer than phencylidine, although the nature of the tolerance developed for both drugs is qualitatively similar, and the significance of these results with respect to putative biochemical tolerance mechanisms is presented and discussed.
References
More filters
Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal Article
Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs
TL;DR: Evidence is presented that phenobarbital induces the synthesis of these enzymes and stimulates liver protein synthesis, and administration of certain drugs enhances the ability of liver microsomes to metabolize the same or a closely related cornpound.
Journal Article
Stimulatory effect of chlorcyclizine on barbiturate metabolism.
Conney Ah,Michaelson Ia,Burns Jj +2 more
TL;DR: Removal of the pituitary gland, adrenal glands or testis did not prevent accelerated barbiturate metabolism by liver microsomes when chlorcyclizine or phenobarbital was administered.
Journal Article
Chronic experimental barbital poisoning
M. H. Seevers,A. L. Tatum +1 more
TL;DR: Experimental evidences herein presented furnish a basis for a more thorough understanding of the problems involved in chronic poisoning and addiction to barbiturates in man.