T
Tom Venken
Researcher at Katholieke Universiteit Leuven
Publications - 25
Citations - 267
Tom Venken is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 16 publications receiving 201 citations. Previous affiliations of Tom Venken include University of Bergen & Flemish Institute for Technological Research.
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Journal ArticleDOI
DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer.
Eva Galle,Bernard Thienpont,Sarah Cappuyns,Tom Venken,Pieter Busschaert,Matthias Van Haele,Eric Van Cutsem,Tania Roskams,Jos van Pelt,Chris Verslype,Jeroen Dekervel,Diether Lambrechts +11 more
TL;DR: Methylation changes underlying EMT are proposed to constitute a common resistance mechanism to cancer therapies and can be reversed pharmacologically and monitored non-invasively in ctDNA to predict resistance to treatment.
Journal ArticleDOI
An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor.
Tom Venken,Daniela Krnavek,Jan Münch,Frank Kirchhoff,Petra Henklein,Marc De Maeyer,Arnout Voet +6 more
TL;DR: In this paper, molecular dynamics were executed in combination with molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) free energy calculations to explore the binding interaction between VIRIP derivatives and gp41 FP.
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A novel method for hydrophobin extraction using CO2 foam fractionation system
Mohammadreza Khalesi,Tom Venken,Sylvie Deckers,James Winterburn,Zahra Shokribousjein,Kurt Gebruers,Hubert Verachtert,Jan A. Delcour,Peter Martin,Guy Derdelinckx +9 more
TL;DR: The gushing potential of samples revealed that in contrast to the samples before CO 2 treatment, interestingly, no gushing was observed for the samples after treatment and the possibility that stable aggregates of HFBII molecules are formed as a consequence of their high concentration is discussed in this paper.
Journal ArticleDOI
Combined Modeling and Biophysical Characterisation of CO2 Interaction with Class II Hydrophobins: New Insight into the Mechanism Underpinning Primary Gushing
Sylvie Deckers,Tom Venken,Mohammadreza Khalesi,Kurt Gebruers,Geert Baggerman,Yannick Lorgouilloux,Zahra Shokribousjein,Vladimir Ilberg,Christina Schönberger,Jean Titze,Hubert Verachtert,Chris W. Michiels,Hedwig Neven,Jan A. Delcour,Johan A. Martens,Guy Derdelinckx,Marc De Maeyer +16 more
TL;DR: A model is proposed that elucidates the “nanobomb” formation depicting a definite chemical and biophysical description of the primary gushing mechanism.
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pKa Modulation of the Acid/Base Catalyst within GH32 and GH68: A Role in Substrate/Inhibitor Specificity?
TL;DR: It is strongly suggested that a highly conserved arginine residue (in the RDP motif) rather than the previously proposed Tyr motif provides the proton to increase the pKa of the acid-base catalyst.