Tomas Hrncir

TL;DR: It is shown that Nod2 plays an essential role in controlling commensal bacterial flora in the intestine by regulating each other through a feedback mechanism, and Dysfunction of Nod1 results in a break-down of this homeostasis.

TL;DR: Oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS).

TL;DR: The data clearly show that not only live gut microbiota but also microbial components (LPS) contained in sterile diet stimulate the development, expansion and function of the immune system.

TL;DR: Lactobacillus paracasei prtP-encoded lactocepin was identified as a protease that selectively degrades secreted, cell-associated, and tissue-distributed IP-10, resulting in significantly reduced lymphocyte recruitment after intraperitoneal injection in an ileitis model.

TL;DR: Only SFB bacteria together with a defined SPF mixture were effective in triggering intestinal inflammation in the model of IBD in reconstituted SCID mice, while no colitis was detected in GF mice or in mice colonized either with SPF microflora or monoassociated only with SFB or colonized by Bacteroides distasonis +SFB or Fusobacterium mortiferum + SFB.