K
Koichi Kobayashi
Researcher at Osaka Prefecture University
Publications - 196
Citations - 16102
Koichi Kobayashi is an academic researcher from Osaka Prefecture University. The author has contributed to research in topics: Innate immune system & Thylakoid. The author has an hindex of 57, co-authored 186 publications receiving 14394 citations. Previous affiliations of Koichi Kobayashi include Hokkaido University & Texas A&M Health Science Center.
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Journal ArticleDOI
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Koichi Kobayashi,Mathias Chamaillard,Yasunori Ogura,Octavian Henegariu,Naohiro Inohara,Gabriel Núñez,Richard A. Flavell +6 more
TL;DR: It is shown that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod1-deficient mice, providing a possible mechanism for Nod 2 mutations in CD.
PatentDOI
IRAK-M is a negative regulator of toll-like receptor signaling
TL;DR: IRAK-M regulates TLR signaling and innate immune homeostasis and prevents dissociation of IRAK and IRAK-4 from MyD88 and formation of IRAk-TRAF6 complexes.
Journal ArticleDOI
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi,Naohiro Inohara,Lorraine D. Hernandez,Jorge E. Galán,Gabriel Núñez,Charles A. Janeway,Ruslan Medzhitov,Richard A. Flavell +7 more
TL;DR: Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems.
Journal ArticleDOI
Nod2 is required for the regulation of commensal microbiota in the intestine
Tanja Petnicki-Ocwieja,Tomas Hrncir,Yuen-Joyce Liu,Amlan Biswas,Tomas Hudcovic,Helena Tlaskalova-Hogenova,Koichi Kobayashi +6 more
TL;DR: It is shown that Nod2 plays an essential role in controlling commensal bacterial flora in the intestine by regulating each other through a feedback mechanism, and Dysfunction of Nod1 results in a break-down of this homeostasis.
Journal ArticleDOI
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Dario S. Zamboni,Koichi Kobayashi,Koichi Kobayashi,Tiana Kohlsdorf,Yasunori Ogura,E Michelle Long,Russell E. Vance,Keisuke Kuida,Sanjeev Mariathasan,Vishva M. Dixit,Richard A. Flavell,William F. Dietrich,Craig R. Roy +12 more
TL;DR: A Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages and in a mouse model of Legionnaires' disease is described.