Tomáš Šimůnek

TL;DR: Several lines of evidence suggest that mechanisms other than the traditionally emphasized "ROS and iron" hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection.

TL;DR: Modification of dosage schedule and synthesis of new anthracycline analogues may represent alternative approaches to mitigate anthrACYcline cardiotoxicity while preserving antitumour activity.

TL;DR: Dexrazoxane may be the key to the enigma of anthracycline cardiotoxicity, and therefore it warrants further investigation, including the search for alternative/complementary modes of cardioprotective action beyond simple iron chelation.

TL;DR: None of the flavonoids tested had betterCardioprotective action than the reference cardioprotector, monoHER, however, a newly synthesized quaternary ammonium analog with comparable cardiop rotective effects has been identified.

TL;DR: Iron chelation is presented as a very powerful tool by which oxidative stress-induced myocardial damage can be prevented.