T
Tommaso Azzarito
Researcher at Istituto Superiore di Sanità
Publications - 13
Citations - 1049
Tommaso Azzarito is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: In vivo & Electrochemotherapy. The author has an hindex of 13, co-authored 13 publications receiving 866 citations.
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Journal ArticleDOI
Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin
Cristina Federici,Francesco Petrucci,Stefano Caimi,Albino Cesolini,Mariantonia Logozzi,Martina Borghi,Sonia D'Ilio,Luana Lugini,Nicola Violante,Tommaso Azzarito,Costanza Majorani,Daria Brambilla,Stefano Fais +12 more
TL;DR: Findings point to the identification of a double mechanism that human malignant melanoma use in resisting to a dreadful cellular poison such as cisplatin, which includes both low pH-dependent extracellular sequestration and an exosome-mediated elimination.
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Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach.
Sophie Taylor,Enrico P. Spugnini,Yehuda G. Assaraf,Tommaso Azzarito,Cyril Rauch,Stefano Fais +5 more
TL;DR: Results provide substantial new evidence that altering the acidic tumor microenvironment is an effective, well tolerated and low cost strategy for the overcoming of anticancer drug resistance.
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Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors.
Elisabetta Iessi,Mariantonia Logozzi,Luana Lugini,Tommaso Azzarito,Cristina Federici,Enrico P. Spugnini,Davide Mizzoni,Rossella Di Raimo,Daniela F. Angelini,Luca Battistini,Serena Cecchetti,Stefano Fais +11 more
TL;DR: This study shows that Exo-AO have a great potential for a real exploitation as a new theranostic approach against tumors based on AO delivered through the exosomes, improving the cytotoxicity of AO.
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Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma
TL;DR: It is shown that PTX and the PPI Lansoprazole (LAN) combination was extremely efficient against metastatic melanoma cells, as compared to the single treatments, both in vitro and in vivo.
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Exosomes: the ideal nanovectors for biodelivery.
Stefano Fais,Mariantonia Logozzi,Luana Lugini,Cristina Federici,Tommaso Azzarito,Natasa Zarovni,Antonio Chiesi +6 more
TL;DR: This review aims to critically emphasize existing data in the literature that support the possible roles of exosomes in both diagnostic and therapeutic scopes, and to consider extracellular vesicles as a whole.