Daniela F. Angelini

TL;DR: Variations of CD161 expression on CD8(+) T cells identify a subset of lymphocytes with proinflammatory characteristics that have not been previously reported in multiple sclerosis and are likely to contribute to disease immunopathology.

TL;DR: This study shows that tumor acidity exerts a selective pressure leading to the release of extracellular vesicles that express both PSA and exosome markers, and suggests that microenvironmental acidity may represent a key factor which determines qualitatively and quantitatively the release.

TL;DR: It is proposed that a favourably modified balance of regulatory and pro-inflammatory lymphocytes underlies the suppression of central nervous system inflammation in patients with multiple sclerosis following non-myeloablative autologous haematopoietic stem cell transplantation with a conditioning regimen consisting of cyclophosphamide and alemtuzumab.

TL;DR: Analysis of specimens obtained from 20 patients revealed that Sam68 is upregulated at the protein level in 35% of the samples and real-time polymerase chain reaction confirmed the results at the mRNA level in most patients.

TL;DR: In this paper, the effector memory Vδ2T lymphocyte population was identified and two distinct and complementary subsets with regard to phenotype, mode of activation, and type of responses can be identified: Vα2TEMh cells, which express high levels of chemokine receptors, but low levels of perforin and of natural killer receptors (NKRs) and which produce large amounts of interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α) in response to T-cell receptor (TC