T
Tomohiro Nakagaki
Researcher at Tokyo Medical and Dental University
Publications - 47
Citations - 1126
Tomohiro Nakagaki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Von Willebrand factor & Protein C. The author has an hindex of 14, co-authored 47 publications receiving 1082 citations.
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Journal ArticleDOI
A Novel Human Metalloprotease Synthesized in the Liver and Secreted into the Blood: Possibly, the von Willebrand Factor—Cleaving Protease?
Kenji Soejima,Noriko Mimura,Masaki Hirashima,Hiroaki Maeda,Takayoshi Hamamoto,Tomohiro Nakagaki,Chikateru Nozaki +6 more
TL;DR: A novel metalloprotease, which could be responsible for cleaving the Tyr842-Met843 peptide bond of von Willebrand factor (vWF), is identified and its genomic DNA was mapped to human chromosome 9q34.
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Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production
Kazunori Murakami,Kenji Okajima,Mitsuhiro Uchiba,Masayoshi Johno,Tomohiro Nakagaki,Hiroaki Okabe,Kiyoshi Takatsuki +6 more
TL;DR: It is suggested that APC prevented LPS-induced pulmonary vascular injury by inhibiting TNF production by monocytes and not via its anticoagulant activity, and the serine protease activity of APC appears to be essential for inhibition of TNFProduction.
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Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects.
Kenji Okajima,Shin Koga,Megumi Kaji,Masayasu Inoue,Tomohiro Nakagaki,Akinobu Funatsu,Hiroaki Okabe,Kiyoshi Takatsuki,Nobuo Aoki +8 more
TL;DR: PC or APC seems to function selectively at the site of thrombin-formation without lowering plasma levels of coagulation factors, as shown in normal human subjects.
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Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood.
Stephanie M. Jung,Masaaki Moroi,Kenji Soejima,Tomohiro Nakagaki,Yoshiki Miura,Michael C. Berndt,Elizabeth E. Gardiner,Joanna Marie Howes,Nicholas Pugh,Dominique Bihan,Steve P. Watson,Richard W. Farndale +11 more
TL;DR: Constitutive GPVI dimers on resting platelets support platelet adhesion to collagen and activation, and will enable them to bind injury-exposed subendothelial collagen to initiate platelet activation.
Journal ArticleDOI
Analysis on the molecular species and concentration of circulating ADAMTS13 in Blood.
Kenji Soejima,Hitomi Nakamura,Masaki Hirashima,Wataru Morikawa,Chikateru Nozaki,Tomohiro Nakagaki +5 more
TL;DR: The results revealed that the region between the disintegrin-like and cysteine-rich/spacer domains interacts with VWF, indicating that the major fraction of ADAMTS13 in blood plasma consisted of the full-length form.