Hiroaki Okabe

TL;DR: The combination of PEG-modified enzymes with alpha-cyclodextrin sulfate provided selectivity for the determination of HDL-cholesterol in serum in the presence of a small amount of dextran sulfate without the need for precipitation of lipoprotein aggregates.

TL;DR: Histological examination revealed that intramedullary hemorrhages observed 24 h after compression at the 12th thoracic vertebra of the spinal cord were significantly attenuated in leukocytopenic animals and those which received the anti-P-selectin monoclonal antibody, suggesting that activated neutrophils play an important role in compression-inducedThoracic spinal cord injury.

TL;DR: The results suggest that the mechanism of APC inhibition of LPS-induced pulmonary vascular injury was independent of its anticoagulant activity and was related to its ability to inhibit accumulation of leukocytes.

TL;DR: A colorimetric micromethod, based on the formation of FFA-Cu soaps, was described for the determination of free fatty acids (FFA) in 100 μl of serum, and 2-(2-thiozolylazo)-p-cresol was chosen for the colorIMetric determination of copper.

TL;DR: It is suggested that APC prevented LPS-induced pulmonary vascular injury by inhibiting TNF production by monocytes and not via its anticoagulant activity, and the serine protease activity of APC appears to be essential for inhibition of TNFProduction.