T
Tomonori Furukawa
Researcher at Hirosaki University
Publications - 34
Citations - 1181
Tomonori Furukawa is an academic researcher from Hirosaki University. The author has contributed to research in topics: GABAergic & GABAA receptor. The author has an hindex of 16, co-authored 30 publications receiving 999 citations. Previous affiliations of Tomonori Furukawa include Saint Louis University & Hamamatsu University School of Medicine.
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Journal ArticleDOI
De Novo Mutations in GNAO1, Encoding a Gαo Subunit of Heterotrimeric G Proteins, Cause Epileptic Encephalopathy
Kazuyuki Nakamura,Kazuyuki Nakamura,Hirofumi Kodera,Tenpei Akita,Masaaki Shiina,Mitsuhiro Kato,Hideki Hoshino,Hiroshi Terashima,Hitoshi Osaka,Shinichi Nakamura,Jun Tohyama,Tatsuro Kumada,Tomonori Furukawa,Satomi Iwata,Takashi Shiihara,Masaya Kubota,Satoko Miyatake,Eriko Koshimizu,Kiyomi Nishiyama,Mitsuko Nakashima,Yoshinori Tsurusaki,Noriko Miyake,Kiyoshi Hayasaka,Kazuhiro Ogata,Atsuo Fukuda,Naomichi Matsumoto,Hirotomo Saitsu +26 more
TL;DR: De novo heterozygous mutations in GNAO1, which encodes a G αo subunit of heterotrimeric G proteins, are identified in four individuals with epileptic encephalopathy, suggesting that aberrant Gαo signaling can cause multiple neurodevelopmental phenotypes, including epilepticEncephalopathy and involuntary movements.
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Dominant-Negative Mutations in α-II Spectrin Cause West Syndrome with Severe Cerebral Hypomyelination, Spastic Quadriplegia, and Developmental Delay
Hirotomo Saitsu,Jun Tohyama,Tatsuro Kumada,Kiyoshi Egawa,Keisuke Hamada,Ippei Okada,Takeshi Mizuguchi,Hitoshi Osaka,Rie Miyata,Tomonori Furukawa,Kazuhiro Haginoya,Hideki Hoshino,Tomohide Goto,Yasuo Hachiya,Takanori Yamagata,Shinji Saitoh,Toshiro Nagai,Kiyomi Nishiyama,Akira Nishimura,Noriko Miyake,Masayuki Komada,Kenji Hayashi,Syu-ichi Hirai,Kazuhiro Ogata,Mitsuhiro Kato,Atsuo Fukuda,Naomichi Matsumoto +26 more
TL;DR: Findings suggest that pathological aggregation of alpha/beta spectrin heterodimers and abnormal AIS integrity resulting from SPTAN1 mutations were involved in pathogenesis of infantile epilepsy.
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GABA-A Receptors Regulate Neocortical Neuronal Migration In Vitro and In Vivo
Nicolas Heck,Werner Kilb,Petra Reiprich,Hisahiko Kubota,Tomonori Furukawa,Atsuo Fukuda,Heiko J. Luhmann +6 more
TL;DR: The results indicate that modulation of GABA-A receptors by compounds acting as agonists or antagonists may profoundly influence the neuronal migration process in the developing cerebral cortex.
Journal ArticleDOI
Molecular Basis for the GABAA Receptor–Mediated Tonic Inhibition in Rat Somatosensory Cortex
TL;DR: Data suggest that the alpha1 GABA(A) receptor subunit is generally involved in tonic inhibition in pyramidal neurons of the neocortex, whereas the alpha5 sub unit is specifically involved in layer V neurons.
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Taurine Inhibits K+-Cl− Cotransporter KCC2 to Regulate Embryonic Cl− Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway
Koichi Inoue,Tomonori Furukawa,Tatsuro Kumada,Junko Yamada,Tianying Wang,Rieko Inoue,Atsuo Fukuda +6 more
TL;DR: In vitro studies revealed that taurine increased KCC2 inactivation in a phosphorylation-dependent manner, which may contribute to embryonic neuronal Cl− homeostasis, which is required for normal brain development.