Kazuhiro Ogata

TL;DR: Findings suggest that haploinsufficiency of STXBP1 causes early infantile epileptic encephalopathy with suppression-burst, and that a mutant form of the protein was significantly thermolabile compared to wild type.

TL;DR: The solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) is determined by heteronuclear multidimensional NMR by determining that both R2 and R3 contain three helices, and the third helix in each is found to be a recognition helix.

TL;DR: By exome sequencing, de novo SMARCB1 mutations are found in two of five individuals with typical Coffin-Siris syndrome (CSS), a rare autosomal dominant anomaly syndrome.

TL;DR: The hydrogen bonding network formed among CBFalpha(Runt domain) and CBFbeta, and the allosteric regulation mechanism of CBF Alpha-Bonded DNA binding by CBF beta revealed theAllosteric Regulation mechanism of C/EBPbeta(bZip)-DNA binding byCBFbeta.

TL;DR: The DNA-binding domain of the c-myb protooncogene product consists of three imperfect tandem repeats of 51 or 52 amino acids, each of which contains three conserved tryptophans, spaced 18 or 19 amino acids apart, which has been determined by NMR with distance geometry calculation.