T
Tomris Mustafa
Researcher at University of Melbourne
Publications - 29
Citations - 1667
Tomris Mustafa is an academic researcher from University of Melbourne. The author has contributed to research in topics: Receptor & Angiotensin II. The author has an hindex of 19, co-authored 29 publications receiving 1538 citations. Previous affiliations of Tomris Mustafa include Royal Melbourne Hospital & National Institutes of Health.
Papers
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Journal ArticleDOI
Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase
Anthony L. Albiston,Sharon G. McDowall,Duana Matsacos,Pamela Sim,Eleanor F. Clune,Tomris Mustafa,Joohyung Lee,Frederick A.O. Mendelsohn,Richard J. Simpson,Lisa M. Connolly,Siew Yeen Chai +10 more
TL;DR: It is demonstrated that the AT4ceptor is IRAP and proposed that AT4 receptor ligands may exert their effects by inhibiting the catalytic activity of IRAP thereby extending the half-life of its neuropeptide substrates.
Journal ArticleDOI
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).
Rebecca A. Lew,Tomris Mustafa,Siying Ye,Sharon G. McDowall,Siew Yeen Chai,Anthony L. Albiston +5 more
TL;DR: It is proposed that the physiological effects of AT4 ligands result, in part, from inhibition of IRAP cleavage of neuropeptides involved in memory processing.
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PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress
TL;DR: It is concluded that chronically elevated CORT is a key component of depressive effects of social defeat, and that attenuation of the CORT response at the level of the PVN, as well as extrahypothalamic forebrain regions, in PACAP-deficient mice protects from development of depressive behavior.
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Distribution of angiotensin IV binding sites (AT4 receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography.
Siew Yeen Chai,Maria A. Bastias,Eleanor F. Clune,Duana Matsacos,Tomris Mustafa,Joohyung Lee,Sharon G. McDowall,George Paxinos,Frederick A.O. Mendelsohn,Anthony L. Albiston +9 more
TL;DR: High densities of 125I[Nle]-angiotensin IV binding sites are found throughout the cerebral cortex including the insular, entorhinal, prefrontal and cingulate cortices and in the hypothalamus, which supports multiple roles for the binding sites in the central nervous system, including facilitation of memory retention and retrieval.
Journal ArticleDOI
AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement.
Anthony L. Albiston,Tomris Mustafa,Sharon G. McDowall,Frederick A.O. Mendelsohn,Joohyung Lee,Siew Yeen Chai +5 more
TL;DR: The potential mechanisms by which angiotensin IV binding to IRAP leads to the facilitation of learning and memory are explored.