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Richard J. Simpson
Researcher at La Trobe University
Publications - 890
Citations - 65907
Richard J. Simpson is an academic researcher from La Trobe University. The author has contributed to research in topics: Peptide sequence & Immune system. The author has an hindex of 113, co-authored 850 publications receiving 59378 citations. Previous affiliations of Richard J. Simpson include University of Wisconsin-Madison & Sir Charles Gairdner Hospital.
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Journal ArticleDOI
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
Anne M. Verhagen,Paul G Ekert,Paul G Ekert,Miha Pakusch,John Silke,Lisa M. Connolly,Gavin E. Reid,Robert L. Moritz,Richard J. Simpson,David L. Vaux +9 more
TL;DR: DIABLO (direct IAP binding protein with low pI) is a novel protein that can bind MIHA and can also interact with MIHB and MIHC and the baculoviral IAP, OpIAP.
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Exosomes: extracellular organelles important in intercellular communication.
TL;DR: This review focuses on various strategies for purifying exosomes and discusses their biophysical and biochemical properties, and an update on proteomic analysis of exosome from various cell types and body fluids is provided and host-cell specific proteomic signatures are discussed.
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Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).
TL;DR: N-terminal region sequence analysis of the molecule has identified the cofactor as beta 2-glycoprotein I (beta 2GPI) (apolipoprotein H), a plasma protein known to bind to anionic phospholipids, indicating that the presence of beta 2G PI is an absolute requirement for antibody-phospholipid interaction.
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Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
Hina Kalra,Richard J. Simpson,Hong Ji,Elena Aikawa,Peter Altevogt,Philip W. Askenase,Vincent C. Bond,Francesc E. Borràs,Xandra O. Breakefield,Vivian Budnik,Edit I. Buzás,Giovanni Camussi,Aled Clayton,Emanuele Cocucci,Juan M. Falcón-Pérez,Susanne Gabrielsson,Yong Song Gho,Dwijendra K. Gupta,H. C. Harsha,An Hendrix,Andrew F. Hill,Jameel M. Inal,Guido Jenster,Eva-Maria Krämer-Albers,Sai Kiang Lim,Alicia Llorente,Jan Lötvall,Antonio Marcilla,Lucia Mincheva-Nilsson,Irina Nazarenko,Rienk Nieuwland,Esther N. M. Nolte-‘t Hoen,Akhilesh Pandey,Tushar Patel,Melissa G. Piper,Stefano Pluchino,T. S. Keshava Prasad,Lawrence Rajendran,Graça Raposo,Michel Record,Gavin E. Reid,Francisco Sánchez-Madrid,Raymond M. Schiffelers,Pia Siljander,Allan Stensballe,Willem Stoorvogel,Douglas D. Taylor,Clotilde Théry,Hadi Valadi,Bas W.M. van Balkom,Jesús Vázquez,Michel Vidal,Marca H. M. Wauben,María Yáñez-Mó,Margot Zoeller,Suresh Mathivanan +55 more
TL;DR: Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles that aims to provide a single authoritative source for information on vesicle structure and function.
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Soil Microorganisms Mediating Phosphorus Availability Update on Microbial Phosphorus
TL;DR: In this paper, the microbial contribution to plant P nutrition and opportunities for manipulating specific microorganisms to enhance P availability in soil has been discussed, as well as the potential for manipulating microorganisms in order to enhance plant P availability.