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Tonghai Zhang
Researcher at Eli Lilly and Company
Publications - 8
Citations - 417
Tonghai Zhang is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: T cell & Sepsis. The author has an hindex of 7, co-authored 8 publications receiving 397 citations.
Papers
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Journal ArticleDOI
Adoptive Transfer of In Vitro-Stimulated CD4+CD25+ Regulatory T Cells Increases Bacterial Clearance and Improves Survival in Polymicrobial Sepsis
Josef G. Heuer,Tonghai Zhang,Jingyong Zhao,Chunjin Ding,Martin S. Cramer,Kathy L. Justen,Steven L. Vonderfecht,Songqing Na +7 more
TL;DR: Adoptive transfer of in vitro-stimulated Tregs in both prevention and therapeutic modes significantly improved survival of cecal ligation and puncture mice and suggest a novel role for T Regs in sepsis.
Journal ArticleDOI
FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.
Kenneth R. Feingold,Carl Grunfeld,Josef G. Heuer,Akanksha Gupta,Martin S. Cramer,Tonghai Zhang,Judy K. Shigenaga,Sophie Patzek,Zoe W. Chan,Arthur H. Moser,Holly A. Bina,Alexei Kharitonenkov +11 more
TL;DR: FGF21 is a positive APR protein that protects animals from the toxic effects of LPS and sepsis, and treatment with exogenous FGF21 reduced the number of animals that die and the rapidity of death after LPS administration in leptin-deficient ob/ob mice and to a lesser extent in control mice.
Journal ArticleDOI
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis.
Josef G. Heuer,Ganesh R. Sharma,Bruce Gerlitz,Tonghai Zhang,Dianna L. Bailey,Chunjin Ding,David T. Berg,Douglas Perkins,Eddie J. Stephens,Kimberly C. Holmes,Renee L. Grubbs,Kelly A. Fynboe,Yun-Fei Chen,Brian W. Grinnell,Joseph A. Jakubowski +14 more
TL;DR: The data from this study indicate that an early decrease in protein C concentration predicts poor outcome in a rat sepsis model and indicates that increases in the CXC chemokines macrophage inflammatory protein-2 and KC precede poor outcome.
Journal ArticleDOI
Enhanced B Cell Expansion, Survival, and Humoral Responses by Targeting Death Receptor 6
Clint S. Schmidt,Jinqi Liu,Tonghai Zhang,Ho Yeong Song,George E. Sandusky,Karen Mintze,Robert J. Benschop,Andrew L. Glasebrook,Derek D. Yang,Songqing Na +9 more
TL;DR: This is the first demonstration of a regulatory role of DR6 in the activation and function of B cells in the presence of T-dependent as well as T-independent type I and II antigens.
Journal ArticleDOI
Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illness.
Josef G. Heuer,Dianna L. Bailey,Ganesh R. Sharma,Tonghai Zhang,Chunjin Ding,Amy M. Ford,Eddie J. Stephens,Kimberly C. Holmes,Renee L. Grubbs,Kelly A. Fynboe,Yun Fei Chen,Joseph A. Jakubowski +11 more
TL;DR: The results indicate that addition of TPN to CLP provides a clinically relevant animal model of critical illness with associated hyperglycemia that may provide utility for the testing of glucoregulatory and other therapeutic modalities.