Josef G. Heuer

TL;DR: Angptl3 and Angptl4 function to regulate circulating triglyceride levels during different nutritional states and therefore play a role in lipid metabolism during feeding/fasting through differential inhibition of LPL.

TL;DR: Adoptive transfer of in vitro-stimulated Tregs in both prevention and therapeutic modes significantly improved survival of cecal ligation and puncture mice and suggest a novel role for T Regs in sepsis.

TL;DR: FGF21 is a positive APR protein that protects animals from the toxic effects of LPS and sepsis, and treatment with exogenous FGF21 reduced the number of animals that die and the rapidity of death after LPS administration in leptin-deficient ob/ob mice and to a lesser extent in control mice.

TL;DR: The data from this study indicate that an early decrease in protein C concentration predicts poor outcome in a rat sepsis model and indicates that increases in the CXC chemokines macrophage inflammatory protein-2 and KC precede poor outcome.

TL;DR: It is shown that a rapid drop in PC after sepsis is strongly associated with an increase in blood urea nitrogen, renal pathology, and expression of known markers of renal injury, including neutrophil gelatinase-associated lipocalin, CXCL1, andCXCL2.