Tongtong Wang

Journal ArticleDOI

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.

- 01 Feb 2019 -

TL;DR: Experimental evidences on the detailed mechanism of DHA‐induced ferroptosis are provided and reveal that DHA might represent a promising therapeutic agent to preferentially target AML cells.

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Journal ArticleDOI

Identification of Frataxin as a regulator of ferroptosis

Jing Du, +17 more

- 01 May 2020 -

Redox biology

TL;DR: It is demonstrated that the protein Frataxin (FXN) is a key regulator of ferroptosis by modulating iron homeostasis and mitochondrial function and pharmacological or genetic blocking the signal of iron starvation could completely restore the resistance to ferroPTosis in FXN knockdown cells and xenograft graft in vivo.

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Journal ArticleDOI

The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia.

Yu Chen, +10 more

- 01 Jan 2018 -

Cellular Physiology and Biochemistry

TL;DR: It is demonstrated that shik onin inhibits CML proliferation and migration and induces apoptosis by the PTEN/PI3K/AKT pathway, revealing the effects of shikonin therapy on CML.

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Journal ArticleDOI

Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement.

Ying Wang, +10 more

- 14 Oct 2016 -

Oncotarget

TL;DR: An unrecognized function of MTE is revealed in inhibiting the proliferation and inducing the apoptosis of T-ALL cells, and a pathway of PTEN/PI3K/AKT/mTOR is identified for the effects of Mte on leukemia therapy.

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Journal ArticleDOI

TEOA Inhibits Proliferation and Induces DNA Damage of Diffuse Large B-Cell Lymphoma Cells Through Activation of the ROS-Dependent p38 MAPK Signaling Pathway.

Xingxing Yu, +12 more

- 04 Sep 2020 -

Frontiers in Pharmacology

TL;DR: Results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage.

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Papers

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.

Identification of Frataxin as a regulator of ferroptosis

The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia.

Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement.

TEOA Inhibits Proliferation and Induces DNA Damage of Diffuse Large B-Cell Lymphoma Cells Through Activation of the ROS-Dependent p38 MAPK Signaling Pathway.