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Xueying Ren
Researcher at Zhejiang Chinese Medical University
Publications - 8
Citations - 421
Xueying Ren is an academic researcher from Zhejiang Chinese Medical University. The author has contributed to research in topics: Medicine & Autophagy. The author has an hindex of 3, co-authored 4 publications receiving 113 citations.
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Journal ArticleDOI
DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.
Jing Du,Tongtong Wang,Yanchun Li,Yi Zhou,Xin Wang,Xingxing Yu,Xueying Ren,Yi-Han An,Yi Wu,Weidong Sun,Fan Weimin,Qiaojuan Zhu,Ying Wang,Xiangmin Tong +13 more
TL;DR: Experimental evidences on the detailed mechanism of DHA‐induced ferroptosis are provided and reveal that DHA might represent a promising therapeutic agent to preferentially target AML cells.
Journal ArticleDOI
Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
Xueying Ren,Yanchun Li,Yi Zhou,Wanye Hu,Chen Yang,Qiangan Jing,Chaoting Zhou,Xu Wang,Jia-Yu Hu,Luyang Wang,Jing Yang,Hairui Wang,Haifeng Xu,Huanjuan Li,Xiangmin Tong,Ying Wang,Jing Du +16 more
TL;DR: In this paper, a series of cellular, molecular, and pharmacological experimental approaches were utilized to address the unrecognized characteristics of disulfiram (DSF), pursuing the goal of repurposing DSF for cancer therapy.
Journal ArticleDOI
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism
Jing Du,Xu Wang,Yanchun Li,Xueying Ren,Yi Zhou,Wanye Hu,Chaoting Zhou,Qiangan Jing,Chen Yang,Luyang Wang,Huanjuan Li,Lijuan Fang,Yong-Lie Zhou,Xiangmin Tong,Ying Wang,Ying Wang +15 more
TL;DR: In this article, a combination of DHA and Cisplatin (DDP) was found to significantly strengthen the cytotoxicity of DDP and significantly reduce its effective concentrations both in vitro and in vivo.
Journal ArticleDOI
Sorafenib induces mitochondrial dysfunction and exhibits synergistic effect with cysteine depletion by promoting HCC cells ferroptosis.
TL;DR: It is found that depletion of cysteine acts synergistically with sorafenib and renders HCC cells vulnerable to ferroptosis, presenting the potential value of new therapeutic combinations for advanced HCC.
Journal ArticleDOI
Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway
Yanchun Li,Bing Xu,Xueying Ren,Luyang Wang,Yaqing Xu,Yefeng Zhao,Chen Yang,Chen Yuan,Hua T. Li,Xiangmin Tong,Ying Wang,Jing Du +11 more
TL;DR: In this paper , the authors investigated the role of CDGSH iron sulfur domain 2 (CISD2) in regulating tumorigenesis and showed that CISD2 depletion significantly accelerated the Erastin-induced ferroptotic cell death with excess lipid peroxidation, GSH exhaustion, and iron accumulation.