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Weidong Sun
Researcher at Bengbu Medical College
Publications - 8
Citations - 332
Weidong Sun is an academic researcher from Bengbu Medical College. The author has contributed to research in topics: Apoptosis & Medicine. The author has an hindex of 3, co-authored 4 publications receiving 152 citations.
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Journal ArticleDOI
DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.
Jing Du,Tongtong Wang,Yanchun Li,Yi Zhou,Xin Wang,Xingxing Yu,Xueying Ren,Yi-Han An,Yi Wu,Weidong Sun,Fan Weimin,Qiaojuan Zhu,Ying Wang,Xiangmin Tong +13 more
TL;DR: Experimental evidences on the detailed mechanism of DHA‐induced ferroptosis are provided and reveal that DHA might represent a promising therapeutic agent to preferentially target AML cells.
Journal ArticleDOI
Identification of Frataxin as a regulator of ferroptosis
Jing Du,Yi Zhou,Yanchun Li,Jun Xia,Yongjian Chen,Sufeng Chen,Xin Wang,Weidong Sun,Tongtong Wang,Xueying Ren,Xu Wang,Yi-Han An,Kang Lu,Wanye Hu,Siyuan Huang,Jianghui Li,Xiangmin Tong,Ying Wang +17 more
TL;DR: It is demonstrated that the protein Frataxin (FXN) is a key regulator of ferroptosis by modulating iron homeostasis and mitochondrial function and pharmacological or genetic blocking the signal of iron starvation could completely restore the resistance to ferroPTosis in FXN knockdown cells and xenograft graft in vivo.
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TEOA Inhibits Proliferation and Induces DNA Damage of Diffuse Large B-Cell Lymphoma Cells Through Activation of the ROS-Dependent p38 MAPK Signaling Pathway.
Xingxing Yu,Xin Wang,Xu Wang,Xu Wang,Yi Zhou,Yanchun Li,Aiwei Wang,Tongtong Wang,Yi-Han An,Weidong Sun,Jing Du,Xiangmin Tong,Ying Wang +12 more
TL;DR: Results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage.
Journal ArticleDOI
[Dihydroartemisinin Induces AML cell Apoptosis by Inhibition of PTEN/AKT pathway].
Yi-Han An,Jing Du,Zhi-Wen Hou,Weidong Sun,Yi Zhou,Xing-Xing Yu,Xin Wang,Ying Wang,Xiangmin Tong +8 more
TL;DR: Dihydroartemisinin is expected to be a safe and effective drug for treatment of acute myeloid leukemia and induces AML cell apoptosis by inhibition of PTEN/AKT pathway.
Journal ArticleDOI
CHMP1A suppresses the growth of renal cell carcinoma cells via regulation of the PI3K/mTOR/p53 signaling pathway
TL;DR: This study showed that the mTOR pathway was suppressed significantly in CHMP1A-overexpressing A498 and 786-0 cells and that CHMP 1A-related suppression of RCC is closely related to the PI3K/mTOR/p53 pathway.