Tony A. Pham

TL;DR: It is found that monocular deprivation leads to an induction of CRE-mediated lacZ expression in the visual cortex preceding the onset of physiologic plasticity, and this induction is dramatically downregulated following the end of the critical period, suggesting that CRE-dependent coordinate regulation of a network of genes may control physiologic Plasticity during postnatal neocortical development.

TL;DR: The results suggest that in development and adulthood, the regulation of a trans-synaptic signaling pathway controls the adaptive potential of cortical circuits.

TL;DR: It is shown that there is a window of CRE/CREB-mediated gene expression in the developing thalamus, which precedes neocortical expression, and this wave of gene expression occurs prior to visual experience, but requires retinal function.

TL;DR: In mice, it was found that four days of monocular deprivation diminished the amplitude of evoked potentials from the deprived eye relative to the non-deprived eye.

TL;DR: In vivo data show that, in contrast to cell culture systems, cortical synaptic activity controls CRE‐mediated gene expression without affecting CREB phosphorylation, possibly by modification of RSK and CREB‐associated coregulators.