Tony B. Jin

TL;DR: To determine the effect of visual inspection on sample size required for studies of MRI‐derived cortical thickness, the number of subjects required to show group differences was calculated and significant differences observed across imaging sites, between visually approved/disapproved subjects, and across regions with different sizes suggest that these measures should be used with caution.

TL;DR: The poor accuracy of classification and predictive results found here reflects current equivocal findings and sheds light on challenges of using these modalities for MDD biomarker identification.

TL;DR: Reduced cortical thickness is a candidate biological marker of depression, although findings are inconsistent and could reflect analytic heterogeneity, such as use of region‐wise cortical thickness based on the Freesurfer Desikan–Killiany atlas or surface‐based morphometry (SBM).

TL;DR: Further evidence is provided to the role of ASL in detecting abnormalities in resting CBF for multiple brain regions including those that are implicated in the default mode network as well as other regions thought to be important in the phenotype of MDD.