T
Tony Velkov
Researcher at University of Melbourne
Publications - 245
Citations - 7607
Tony Velkov is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polymyxin & Polymyxin B. The author has an hindex of 39, co-authored 214 publications receiving 5500 citations. Previous affiliations of Tony Velkov include Northeast Agricultural University & Monash University, Parkville campus.
Papers
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Journal ArticleDOI
Structure—Activity Relationships of Polymyxin Antibiotics
TL;DR: This research presents a novel and scalable approaches that allow for real-time decision-making in the design and implementation of drug 505(b) agonist regimens for the treatment of central nervous system disorders.
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Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.
TL;DR: In this paper, the authors survey the significant progress over the last decade in understanding polymyxin chemistry, mechanisms of antibacterial activity and resistance, structure-activity relationships and pharmacokinetics/pharmacodynamics.
Journal ArticleDOI
Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?
TL;DR: The view that overall polymyxin B has superior clinical pharmacological properties compared with CMS/colistin is put forth, and it is proposed that in countries such as the United States where parenteral products of both colistin and polymyXin B are available, prospective studies should be conducted to formally examine their relative efficacy and safety in various types of infections and patients.
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A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
Zakuan Zainy Deris,Jesmin Akter,Sivashangarie Sivanesan,Kade D. Roberts,Philip E. Thompson,Roger L. Nation,Jian Li,Tony Velkov +7 more
TL;DR: It is suggested that the inhibition of vital respiratory enzymes in the bacterial inner membrane represents one of the secondary modes of action for polymyxins in response to ubiquinone-1 and NADH.
Journal ArticleDOI
The rise and spread of mcr plasmid-mediated polymyxin resistance
Sue C Nang,Jian Li,Tony Velkov +2 more
TL;DR: The epidemiological, microbiological and genomics aspects of this emerging threat to global human health with the global dissemination of mcr, plasmid-mediated polymyxin resistance are covered.