Philip E. Thompson

TL;DR: This research presents a novel and scalable approaches that allow for real-time decision-making in the design and implementation of drug 505(b) agonist regimens for the treatment of central nervous system disorders.

TL;DR: This study has defined a key role for the Type Ia phosphoinositide 3-kinase (PI3K) p110β isoform in regulating the formation and stability of integrin αIIbβ3 adhesion bonds, necessary for shear activation of platelets, as an important new target for antithrombotic therapy.

TL;DR: In this paper, the authors survey the significant progress over the last decade in understanding polymyxin chemistry, mechanisms of antibacterial activity and resistance, structure-activity relationships and pharmacokinetics/pharmacodynamics.

TL;DR: It is shown that mouse and human granzyme B have distinct structural and functional characteristics, and it is demonstrated that even “orthologous” granzymes have species-specific functions, having evolved in distinct environments that pose different challenges.

TL;DR: Gingipain‐R, the major arginine‐specific proteinase from Porphyromonas gingivalis, was found to cleave a model peptide representing the cleavage site of proteinase‐activated receptor‐2 (PAR‐2), a G‐protein‐coupled receptor found on the surface of neutrophils, which may be a mechanism for the development of inflammation associated with periodontal disease.